{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ahn JH"],"funding":["National Research Foundation of Korea"],"pagination":["8397"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6557891"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(1)"],"pubmed_abstract":["Inhibitor of kappa B (IκB)-ζ transcription is rapidly induced by stimulation with TLR ligands and IL-1. Despite high IκBζ expression in inflammation sites, the association of IκBζ with host defence via systemic immune responses against bacterial infection remains unclear. Oral immunisation with a recombinant attenuated Salmonella vaccine (RASV) strain did not protect IκBζ-deficient mice against a lethal Salmonella challenge. IκBζ-deficient mice failed to produce Salmonella LPS-specific IgG, especially IgG2a, although inflammatory cytokine production and immune cell infiltration into the liver increased after oral RASV administration. Moreover, IκBζ-deficient mice exhibited enhanced splenic germinal centre reactions followed by increased total IgG production, despite IκBζ-deficient B cells "],"journal":["Scientific reports"],"pubmed_title":["IκBζ facilitates protective immunity against Salmonella infection via Th1 differentiation and IgG production."],"pmcid":["PMC6557891"],"funding_grant_id":["NRF-2017R1A2B2001963","NRF-2016R1A4A1010115","NRF-2017M3A9C8060387"],"pubmed_authors":["Ahn JH","Yang H","Yoon SI","Kwon BE","Chang SY","Kweon MN","Lee GS","Ko HJ","Kang SG","Kim YI","Cho J","Kim PH","Vallance BA"],"additional_accession":[]},"is_claimable":false,"name":"IκBζ facilitates protective immunity against Salmonella infection via Th1 differentiation and IgG production.","description":"Inhibitor of kappa B (IκB)-ζ transcription is rapidly induced by stimulation with TLR ligands and IL-1. Despite high IκBζ expression in inflammation sites, the association of IκBζ with host defence via systemic immune responses against bacterial infection remains unclear. Oral immunisation with a recombinant attenuated Salmonella vaccine (RASV) strain did not protect IκBζ-deficient mice against a lethal Salmonella challenge. IκBζ-deficient mice failed to produce Salmonella LPS-specific IgG, especially IgG2a, although inflammatory cytokine production and immune cell infiltration into the liver increased after oral RASV administration. Moreover, IκBζ-deficient mice exhibited enhanced splenic germinal centre reactions followed by increased total IgG production, despite IκBζ-deficient B cells ","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Jun","modification":"2025-04-04T22:09:25.949Z","creation":"2019-07-24T07:13:56Z"},"accession":"S-EPMC6557891","cross_references":{"pubmed":["31182790"],"doi":["10.1038/s41598-019-44019-3"]}}