{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10"],"submitter":["Calonga-Solis V"],"pubmed_abstract":["Even though immunoglobulins are critical for immune responses and human survival, the diversity of the immunoglobulin heavy chain gene (<i>IGH</i>) is poorly known and mostly characterized only by serological methods. Moreover, this genomic region is not well-covered in genomic databases and genome-wide association studies due to particularities that impose technical difficulties for its analysis. Therefore, the <i>IGH</i> gene has never been systematically sequenced across populations. Here, we deliver an unprecedented and comprehensive characterization of the diversity of the <i>IGHG1, IGHG2</i>, and <i>IGHG3</i> gene segments, which encode the constant region of the most abundant circulating immunoglobulins: IgG1, IgG2, and IgG3, respectively. We used Sanger sequencing to analyze 357 in"],"journal":["Frontiers in immunology"],"pagination":["1161"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6558194"],"repository":["biostudies-literature"],"pubmed_title":["Unveiling the Diversity of Immunoglobulin Heavy Constant Gamma (<i>IGHG</i>) Gene Segments in Brazilian Populations Reveals 28 Novel Alleles and Evidence of Gene Conversion and Natural Selection."],"pmcid":["PMC6558194"],"pubmed_authors":["Calonga-Solis V","Vargas LB","Wassem R","Malheiros D","Augusto DG","Beltrame MH","Petzl-Erler ML","Issler HC","Dourado RM"],"additional_accession":[]},"is_claimable":false,"name":"Unveiling the Diversity of Immunoglobulin Heavy Constant Gamma (<i>IGHG</i>) Gene Segments in Brazilian Populations Reveals 28 Novel Alleles and Evidence of Gene Conversion and Natural Selection.","description":"Even though immunoglobulins are critical for immune responses and human survival, the diversity of the immunoglobulin heavy chain gene (<i>IGH</i>) is poorly known and mostly characterized only by serological methods. Moreover, this genomic region is not well-covered in genomic databases and genome-wide association studies due to particularities that impose technical difficulties for its analysis. Therefore, the <i>IGH</i> gene has never been systematically sequenced across populations. Here, we deliver an unprecedented and comprehensive characterization of the diversity of the <i>IGHG1, IGHG2</i>, and <i>IGHG3</i> gene segments, which encode the constant region of the most abundant circulating immunoglobulins: IgG1, IgG2, and IgG3, respectively. We used Sanger sequencing to analyze 357 in","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019","modification":"2026-04-29T03:43:14.396Z","creation":"2019-07-24T07:14:06Z"},"accession":"S-EPMC6558194","cross_references":{"pubmed":["31214166"],"doi":["10.3389/fimmu.2019.01161"]}}