biostudies-literatureHair KStroke AssociationMedical Research CouncilWellcome Trust12https://www.ebi.ac.uk/biostudies/studies/S-EPMC6560728biostudies-literatureUnknown4<h4>Background</h4>The ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines are widely endorsed but compliance is limited. We sought to determine whether journal-requested completion of an ARRIVE checklist improves full compliance with the guidelines.<h4>Methods</h4>In a randomised controlled trial, manuscripts reporting in vivo animal research submitted to PLOS ONE (March-June 2015) were randomly allocated to either requested completion of an ARRIVE checklist or current standard practice. Authors, academic editors, and peer reviewers were blinded to group allocation. Trained reviewers performed outcome adjudication in duplicate by assessing manuscripts against an operationalised version of the ARRIVE guidelines that consists 108 items. Our primary outcome was the between-Research integrity and peer reviewA randomised controlled trial of an Intervention to Improve Compliance with the ARRIVE guidelines (IICARus).PMC6560728SAL-SNC18/1003MR/N004574/1Currie GLCascella MO'Connor LDingwall MBahor ZBaker DClark ACramond FWarda MCheyne RRinaldi AWever KEIICARus CollaborationMoreland RHowells DDe-Souza EABath PSena ESCharbonney EChristopher EGrill PNazzal AQuinn TJLynn SAMcCann SKMacleod MRStorey JMorrison GShek AJones VKonold TAlvino GIrvine CMarcu DCHosh MHair KGray LJDohm MHohendorf VDevonshire IMLiao JAntar SGerlei KZBannach-Brown ACorke SMacCallum CFreymann JBaginskaite Jde Oliveira CLJheeta PTanriver-Ayder EHenshall DESena CKarp NAGregorc TBlazek KAmmar ZWheater ERoncon PLaban KfalseA randomised controlled trial of an Intervention to Improve Compliance with the ARRIVE guidelines (IICARus).<h4>Background</h4>The ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines are widely endorsed but compliance is limited. We sought to determine whether journal-requested completion of an ARRIVE checklist improves full compliance with the guidelines.<h4>Methods</h4>In a randomised controlled trial, manuscripts reporting in vivo animal research submitted to PLOS ONE (March-June 2015) were randomly allocated to either requested completion of an ARRIVE checklist or current standard practice. Authors, academic editors, and peer reviewers were blinded to group allocation. Trained reviewers performed outcome adjudication in duplicate by assessing manuscripts against an operationalised version of the ARRIVE guidelines that consists 108 items. Our primary outcome was the between-2019-01-01T00:00:00Z20192025-04-04T18:36:51.102Z2019-07-24T07:15:17ZS-EPMC65607283120575610.1186/s41073-019-0069-3