{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Warren BD"],"funding":["NICHD NIH HHS","National Institutes of Health","NIGMS NIH HHS","IDeA Network of Biomedical Research Excellence"],"pagination":["1492-1504"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6561863"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["100(6)"],"pubmed_abstract":["Autoimmune Regulator (AIRE) regulates central immune tolerance by inducing expression of tissue-restricted antigens in thymic medullary epithelial cells, thereby ensuring elimination of autoreactive T cells. Aire mutations in humans and targeted Aire deletion in mice result in multiorgan autoimmune disease, known in humans as autoimmune polyglandular syndrome type 1 (APS-1). APS-1 is characterized by the presence of adrenal insufficiency, chronic mucosal candidiasis, and/or hypoparathyroidism. Additionally, females often present with gonadal insufficiency and infertility. Aire-deficiency (KO) in mice results in oophoritis and age-dependent depletion of follicular reserves. Here, we found that while the majority of young 6-week-old Aire-KO females had normal follicular reserves, mating beha"],"journal":["Biology of reproduction"],"pubmed_title":["Autoimmune Regulator is required in female mice for optimal embryonic development and implantation†."],"pmcid":["PMC6561863"],"funding_grant_id":["GM103418","P20 GM104936","P20 GM103418","R21 HD082484","HD042280","R01 HD045611","HD082484","R21 HD062879","HD045611","R01 HD042280","HD062879"],"pubmed_authors":["Grzesiak G","Su RW","Petroff BK","Petroff MG","McGinnis LK","Ahn SH","Warren BD","Fazleabas AT","Christenson LK"],"additional_accession":[]},"is_claimable":false,"name":"Autoimmune Regulator is required in female mice for optimal embryonic development and implantation†.","description":"Autoimmune Regulator (AIRE) regulates central immune tolerance by inducing expression of tissue-restricted antigens in thymic medullary epithelial cells, thereby ensuring elimination of autoreactive T cells. Aire mutations in humans and targeted Aire deletion in mice result in multiorgan autoimmune disease, known in humans as autoimmune polyglandular syndrome type 1 (APS-1). APS-1 is characterized by the presence of adrenal insufficiency, chronic mucosal candidiasis, and/or hypoparathyroidism. Additionally, females often present with gonadal insufficiency and infertility. Aire-deficiency (KO) in mice results in oophoritis and age-dependent depletion of follicular reserves. Here, we found that while the majority of young 6-week-old Aire-KO females had normal follicular reserves, mating beha","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Jun","modification":"2025-04-18T22:08:58.323Z","creation":"2025-04-07T09:58:16.073Z"},"accession":"S-EPMC6561863","cross_references":{"pubmed":["30770532"],"doi":["10.1093/biolre/ioz023"]}}