biostudies-literatureGao ZBasic projects of the Shanghai Science and Technology CommitteeE291https://www.ebi.ac.uk/biostudies/studies/S-EPMC6562635biostudies-literatureUnknown10(5)In droplet-based microfluidics, visualizing and modulating of droplets is often prerequisite. In this paper, we report a facile strategy for visualizing and modulating high-throughput droplets in microfluidics. In the strategy, by modulating the sampling frequency of a flash light with the droplet frequency, we are able to map a real high frequency signal to a low frequency signal, which facilitates visualizing and feedback controlling. Meanwhile, because of not needing synchronization signals, the strategy can be directly implemented on any droplet-based microfluidic chips. The only cost of the strategy is an additional signal generator. Moreover, the strategy can catch droplets with frequency up to several kilohertz, which covers the range of most high-throughput droplet-based microfluidMicromachinesA Facile Strategy for Visualizing and Modulating Droplet-Based Microfluidics.PMC6562635YJKYYQ20170043No. 17441904300Peng HZhu MWu LJia CGao ZZhou HZhao JfalseA Facile Strategy for Visualizing and Modulating Droplet-Based Microfluidics.In droplet-based microfluidics, visualizing and modulating of droplets is often prerequisite. In this paper, we report a facile strategy for visualizing and modulating high-throughput droplets in microfluidics. In the strategy, by modulating the sampling frequency of a flash light with the droplet frequency, we are able to map a real high frequency signal to a low frequency signal, which facilitates visualizing and feedback controlling. Meanwhile, because of not needing synchronization signals, the strategy can be directly implemented on any droplet-based microfluidic chips. The only cost of the strategy is an additional signal generator. Moreover, the strategy can catch droplets with frequency up to several kilohertz, which covers the range of most high-throughput droplet-based microfluid2019-01-01T00:00:00Z2019 Apr2025-04-18T18:57:39.657Z2019-07-24T07:16:19ZS-EPMC65626353103544610.3390/mi10050291