biostudies-literatureGallab MCouncil for Science, Technology and InnovationE297https://www.ebi.ac.uk/biostudies/studies/S-EPMC6562714biostudies-literatureUnknown10(5)Three-dimensional (3D) microfluidic channels, which simulate human tissues such as blood vessels, are useful in surgical simulator models for evaluating surgical devices and training novice surgeons. However, animal models and current artificial models do not sufficiently mimic the anatomical and mechanical properties of human tissues. Therefore, we established a novel fabrication method to fabricate an eye model for use as a surgical simulator. For the glaucoma surgery task, the eye model consists of a sclera with a clear cornea; a 3D microchannel with a width of 200-500 µm, representing the Schlemm's canal (SC); and a thin membrane with a thickness of 40-132 µm, representing the trabecular meshwork (TM). The sclera model with a clear cornea and SC was fabricated by 3D molding. Blow moldiMicromachinesDevelopment of a Spherical Model with a 3D Microchannel: An Application to Glaucoma Surgery.PMC6562714the ImPACT ProgramUeta TArai FGallab MAraki FAihara MTotsuka KOmata STakao MSugimoto KHarada KMitsuishi MfalseDevelopment of a Spherical Model with a 3D Microchannel: An Application to Glaucoma Surgery.Three-dimensional (3D) microfluidic channels, which simulate human tissues such as blood vessels, are useful in surgical simulator models for evaluating surgical devices and training novice surgeons. However, animal models and current artificial models do not sufficiently mimic the anatomical and mechanical properties of human tissues. Therefore, we established a novel fabrication method to fabricate an eye model for use as a surgical simulator. For the glaucoma surgery task, the eye model consists of a sclera with a clear cornea; a 3D microchannel with a width of 200-500 µm, representing the Schlemm's canal (SC); and a thin membrane with a thickness of 40-132 µm, representing the trabecular meshwork (TM). The sclera model with a clear cornea and SC was fabricated by 3D molding. Blow moldi2019-01-01T00:00:00Z2019 Apr2025-04-05T10:41:27.197Z2019-07-24T07:16:21ZS-EPMC65627143105232410.3390/mi10050297