{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liu J"],"funding":["Economic and Social Research Council","European Research Council","NIA NIH HHS","NIDDK NIH HHS","NHLBI NIH HHS","Dutch Research Council (NWO)","ZonMw","Biotechnology and Biological Sciences Research Council"],"pagination":["2581"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6565679"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(1)"],"pubmed_abstract":["Despite existing reports on differential DNA methylation in type 2 diabetes (T2D) and obesity, our understanding of its functional relevance remains limited. Here we show the effect of differential methylation in the early phases of T2D pathology by a blood-based epigenome-wide association study of 4808 non-diabetic Europeans in the discovery phase and 11,750 individuals in the replication. We identify CpGs in LETM1, RBM20, IRS2, MAN2A2 and the 1q25.3 region associated with fasting insulin, and in FCRL6, SLAMF1, APOBEC3H and the 15q26.1 region with fasting glucose. In silico cross-omics analyses highlight the role of differential methylation in the crosstalk between the adaptive immune system and glucose homeostasis. The differential methylation explains at least 16.9% of the association b"],"journal":["Nature communications"],"pubmed_title":["An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis."],"pmcid":["PMC6565679"],"funding_grant_id":["U01 AG061359","BB/S020845/1","R01 HL133221","R01 HL120393","91616165","ES/N000404/1","U01 HL120393","K01 HL130609","648916","K24 DK080140","VIDI 016.136.361","U01 DK078616","R01 HL105756"],"pubmed_authors":["Grallert H","Dupuis J","Rotter JI","Bressler J","Uitterlinden AG","Franco OH","Chu AY","van Dijk KW","Whitsel EA","Moore AZ","Ferrucci L","Spector TD","Dehghan A","Willemsen G","Hivert MF","Tiemeier H","van Duijn CM","Felix JF","Peters MJ","Levy D","Assimes TL","Pankow JS","Nedeljkovic I","Duijts L","Bell JT","Liu J","Amin N","Meigs JB","de Geus EJC","Salfati EL","Sijbrands EJG","van Meurs JBJ","Sotoodehnia N","van Dongen J","Martin TC","Hwang SJ","Jaddoe VWV","Bandinelli S","Isaacs A","Gondalia R","Tanaka T","Lemaitre RN","Arnett DK","Smith JA","Baccarelli A","Carnero-Montoro E","Lent S","Tsai PC","Mandaviya PR","Boomsma DI","Demirkan A","Hou L","Jhun MA","Ligthart S","Jansen R","Herder C","Hidalgo BA"],"additional_accession":[]},"is_claimable":false,"name":"An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis.","description":"Despite existing reports on differential DNA methylation in type 2 diabetes (T2D) and obesity, our understanding of its functional relevance remains limited. Here we show the effect of differential methylation in the early phases of T2D pathology by a blood-based epigenome-wide association study of 4808 non-diabetic Europeans in the discovery phase and 11,750 individuals in the replication. We identify CpGs in LETM1, RBM20, IRS2, MAN2A2 and the 1q25.3 region associated with fasting insulin, and in FCRL6, SLAMF1, APOBEC3H and the 15q26.1 region with fasting glucose. In silico cross-omics analyses highlight the role of differential methylation in the crosstalk between the adaptive immune system and glucose homeostasis. The differential methylation explains at least 16.9% of the association b","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Jun","modification":"2026-05-07T13:33:36.68Z","creation":"2019-07-24T07:17:24Z"},"accession":"S-EPMC6565679","cross_references":{"pubmed":["31197173"],"doi":["10.1038/s41467-019-10487-4"]}}