biostudies-literatureNishimura Mthe Project of the NARO Bio-oriented Technology Research Advancement Institution (the special scheme project on regional developing strategy).E1177https://www.ebi.ac.uk/biostudies/studies/S-EPMC6566250biostudies-literatureUnknown11(5)Tomato (<i>Solanum lycopersicum</i>) is a rich source of lycopene, a carotenoid that confers various positive biological effects such as improved lipid metabolism. Here, we conducted a randomized, double-blind, placebo-controlled, parallel-group comparative study to investigate the effects of regular and continuous intake of a new high-lycopene tomato, a variety named PR-7, for 12 weeks, based on 74 healthy Japanese subjects with low-density lipoprotein cholesterol (LDL-C) levels ≥120 to <160 mg/dL. The subjects were randomly assigned to either the high-lycopene tomato or placebo (lycopene-free tomato) group. Each subject in the high-lycopene group ingested 50 g of semidried PR-7 (lycopene, 22.0-27.8 mg/day) each day for 12 weeks, while subjects in the placebo group ingested placebo semidrNutrientsEffect of 12-Week Daily Intake of the High-Lycopene Tomato (<i>Solanum Lycopersicum</i>), A Variety Named "PR-7", on Lipid Metabolism: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study.PMC656625016797811Ishikawa-Takano YNishimura MNishihira JTominaga NMaeda-Yamamoto MfalseEffect of 12-Week Daily Intake of the High-Lycopene Tomato (<i>Solanum Lycopersicum</i>), A Variety Named "PR-7", on Lipid Metabolism: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study.Tomato (<i>Solanum lycopersicum</i>) is a rich source of lycopene, a carotenoid that confers various positive biological effects such as improved lipid metabolism. Here, we conducted a randomized, double-blind, placebo-controlled, parallel-group comparative study to investigate the effects of regular and continuous intake of a new high-lycopene tomato, a variety named PR-7, for 12 weeks, based on 74 healthy Japanese subjects with low-density lipoprotein cholesterol (LDL-C) levels ≥120 to <160 mg/dL. The subjects were randomly assigned to either the high-lycopene tomato or placebo (lycopene-free tomato) group. Each subject in the high-lycopene group ingested 50 g of semidried PR-7 (lycopene, 22.0-27.8 mg/day) each day for 12 weeks, while subjects in the placebo group ingested placebo semidr2019-01-01T00:00:00Z2019 May2025-06-01T02:54:53.426Z2025-06-01T02:54:53.426ZS-EPMC65662503113066810.3390/nu11051177