{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Midford PE"],"funding":["National Cancer Institute"],"pagination":["E88"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6571860"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(5)"],"pubmed_abstract":["Interpreting changes in metabolite abundance in response to experimental treatments or disease states remains a major challenge in metabolomics. Pathway Covering is a new algorithm that takes a list of metabolites (compounds) and determines a minimum-cost set of metabolic pathways in an organism that includes (covers) all the metabolites in the list. We used five functions for assigning costs to pathways, including assigning a constant for all pathways, which yields a solution with the smallest pathway count; two methods that penalize large pathways; one that prefers pathways based on the pathway's assigned function, and one that loosely corresponds to metabolic flux. The pathway covering set computed by the algorithm can be displayed as a multi-pathway diagram (\"pathway collage\") that hig"],"journal":["Metabolites"],"pubmed_title":["Using Pathway Covering to Explore Connections among Metabolites."],"pmcid":["PMC6571860"],"funding_grant_id":["R03-CA211814"],"pubmed_authors":["Karp PD","Latendresse M","O'Maille PE","Midford PE"],"additional_accession":[]},"is_claimable":false,"name":"Using Pathway Covering to Explore Connections among Metabolites.","description":"Interpreting changes in metabolite abundance in response to experimental treatments or disease states remains a major challenge in metabolomics. Pathway Covering is a new algorithm that takes a list of metabolites (compounds) and determines a minimum-cost set of metabolic pathways in an organism that includes (covers) all the metabolites in the list. We used five functions for assigning costs to pathways, including assigning a constant for all pathways, which yields a solution with the smallest pathway count; two methods that penalize large pathways; one that prefers pathways based on the pathway's assigned function, and one that loosely corresponds to metabolic flux. The pathway covering set computed by the algorithm can be displayed as a multi-pathway diagram (\"pathway collage\") that hig","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 May","modification":"2025-04-06T11:52:05.965Z","creation":"2019-07-24T07:19:21Z"},"accession":"S-EPMC6571860","cross_references":{"pubmed":["31052521"],"doi":["10.3390/metabo9050088"]}}