{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Perng W"],"funding":["National Institutes of Health"],"pagination":["E100"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6572261"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(5)"],"pubmed_abstract":["We sought to identify metabolites that mark the relationship of sugar-sweetened beverage (SSB) intake with adiposity and metabolic risk among boys (n = 114) and girls (n = 128) aged 8-14 years. We conducted the analysis in three steps: (1) linear regression to examine associations of SSB intake (quartiles) with adiposity, glycemia, lipids, and blood pressure (BP); (2) least absolute shrinkage and selection operator (LASSO) regression to identify SSB-associated metabolites from an untargeted dataset of 938 metabolites; and (3) linear regression to determine whether SSB-related metabolites are also associated with adiposity and metabolic risk. In girls, SSB intake was associated with marginally higher BP (Q2 vs, Q1: 1.11 [-3.90, 6.13], Q3 vs. Q1: 1.16 [-3.81, 6.13], Q4 vs. Q1: 4.65 [-0.22, 9"],"journal":["Metabolites"],"pubmed_title":["Urate and Nonanoate Mark the Relationship between Sugar-Sweetened Beverage Intake and Blood Pressure in Adolescent Girls: A Metabolomics Analysis in the ELEMENT Cohort."],"pmcid":["PMC6572261"],"funding_grant_id":["P30 DK089503","P01ES022844"],"pubmed_authors":["Tang L","Tellez Rojo MM","Perng W","Peterson KE","Cantoral A","Goran M","Song PXK"],"additional_accession":[]},"is_claimable":false,"name":"Urate and Nonanoate Mark the Relationship between Sugar-Sweetened Beverage Intake and Blood Pressure in Adolescent Girls: A Metabolomics Analysis in the ELEMENT Cohort.","description":"We sought to identify metabolites that mark the relationship of sugar-sweetened beverage (SSB) intake with adiposity and metabolic risk among boys (n = 114) and girls (n = 128) aged 8-14 years. We conducted the analysis in three steps: (1) linear regression to examine associations of SSB intake (quartiles) with adiposity, glycemia, lipids, and blood pressure (BP); (2) least absolute shrinkage and selection operator (LASSO) regression to identify SSB-associated metabolites from an untargeted dataset of 938 metabolites; and (3) linear regression to determine whether SSB-related metabolites are also associated with adiposity and metabolic risk. In girls, SSB intake was associated with marginally higher BP (Q2 vs, Q1: 1.11 [-3.90, 6.13], Q3 vs. Q1: 1.16 [-3.81, 6.13], Q4 vs. Q1: 4.65 [-0.22, 9","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 May","modification":"2025-04-26T06:25:20.983Z","creation":"2019-07-24T07:19:31Z"},"accession":"S-EPMC6572261","cross_references":{"pubmed":["31108933"],"doi":["10.3390/metabo9050100"]}}