biostudies-literaturePerng WNational Institutes of HealthE100https://www.ebi.ac.uk/biostudies/studies/S-EPMC6572261biostudies-literatureUnknown9(5)We sought to identify metabolites that mark the relationship of sugar-sweetened beverage (SSB) intake with adiposity and metabolic risk among boys (n = 114) and girls (n = 128) aged 8-14 years. We conducted the analysis in three steps: (1) linear regression to examine associations of SSB intake (quartiles) with adiposity, glycemia, lipids, and blood pressure (BP); (2) least absolute shrinkage and selection operator (LASSO) regression to identify SSB-associated metabolites from an untargeted dataset of 938 metabolites; and (3) linear regression to determine whether SSB-related metabolites are also associated with adiposity and metabolic risk. In girls, SSB intake was associated with marginally higher BP (Q2 vs, Q1: 1.11 [-3.90, 6.13], Q3 vs. Q1: 1.16 [-3.81, 6.13], Q4 vs. Q1: 4.65 [-0.22, 9MetabolitesUrate and Nonanoate Mark the Relationship between Sugar-Sweetened Beverage Intake and Blood Pressure in Adolescent Girls: A Metabolomics Analysis in the ELEMENT Cohort.PMC6572261P30 DK089503P01ES022844Tang LTellez Rojo MMPerng WPeterson KECantoral AGoran MSong PXKfalseUrate and Nonanoate Mark the Relationship between Sugar-Sweetened Beverage Intake and Blood Pressure in Adolescent Girls: A Metabolomics Analysis in the ELEMENT Cohort.We sought to identify metabolites that mark the relationship of sugar-sweetened beverage (SSB) intake with adiposity and metabolic risk among boys (n = 114) and girls (n = 128) aged 8-14 years. We conducted the analysis in three steps: (1) linear regression to examine associations of SSB intake (quartiles) with adiposity, glycemia, lipids, and blood pressure (BP); (2) least absolute shrinkage and selection operator (LASSO) regression to identify SSB-associated metabolites from an untargeted dataset of 938 metabolites; and (3) linear regression to determine whether SSB-related metabolites are also associated with adiposity and metabolic risk. In girls, SSB intake was associated with marginally higher BP (Q2 vs, Q1: 1.11 [-3.90, 6.13], Q3 vs. Q1: 1.16 [-3.81, 6.13], Q4 vs. Q1: 4.65 [-0.22, 92019-01-01T00:00:00Z2019 May2025-04-26T06:25:20.983Z2019-07-24T07:19:31ZS-EPMC65722613110893310.3390/metabo9050100