biostudies-literatureHitchcock CEconomic and Social Research CouncilMedical Research Councile031110https://www.ebi.ac.uk/biostudies/studies/S-EPMC6575822biostudies-literatureUnknown9(6)<h4>Introduction</h4>Cognitive behavioural therapies (CBTs) are one of the most effective treatments for major depression. However, ~50% of individuals do not adequately respond to intervention and of those who do remit from a depressive episode, over 50% will experience later relapse. Identification of patient-level factors which moderate treatment response may ultimately help to identify cognitive barriers that could be targeted to improve treatment efficacy. This individual patient data meta-analysis explores one such potential moderator-the ability to retrieve specific, detailed memories of the autobiographical past-as cognitive-based therapeutic techniques draw heavily on the ability to use specific autobiographical information to challenge the dysfunctional beliefs which drive depresBMJ openRole of autobiographical memory in patient response to cognitive behavioural therapies for depression: protocol of an individual patient data meta-analysis.PMC6575822ES/R010781/1MC_UU_00005/4MC_U105579215Dalgleish TKuhn IHitchcock CPatel SSmith AWatkins ERudokaite JfalseRole of autobiographical memory in patient response to cognitive behavioural therapies for depression: protocol of an individual patient data meta-analysis.<h4>Introduction</h4>Cognitive behavioural therapies (CBTs) are one of the most effective treatments for major depression. However, ~50% of individuals do not adequately respond to intervention and of those who do remit from a depressive episode, over 50% will experience later relapse. Identification of patient-level factors which moderate treatment response may ultimately help to identify cognitive barriers that could be targeted to improve treatment efficacy. This individual patient data meta-analysis explores one such potential moderator-the ability to retrieve specific, detailed memories of the autobiographical past-as cognitive-based therapeutic techniques draw heavily on the ability to use specific autobiographical information to challenge the dysfunctional beliefs which drive depres2019-01-01T00:00:00Z2019 Jun2025-04-05T12:41:03.672Z2019-07-24T07:20:03ZS-EPMC65758223119690710.1136/bmjopen-2019-031110