biostudies-literatureBrigham EPNCATS NIH HHSNIEHS NIH HHSNHLBI NIH HHS1478-1486https://www.ebi.ac.uk/biostudies/studies/S-EPMC6580674biostudies-literatureUnknown199(12)<b>Rationale:</b> Higher indoor particulate matter (PM) concentrations are linked with increased asthma morbidity. Dietary intake of fatty acids, also linked with asthma outcomes, may influence this relationship. <b>Objectives:</b> To determine the relationship between omega-3 and omega-6 fatty acid intake and pediatric asthma morbidity, and the association between fatty acid intake and strength of indoor, PM-related asthma symptoms, albuterol use, and systemic inflammation. <b>Methods:</b> Analyses included 135 children with asthma enrolled in the AsthmaDIET Study. At baseline, 3 months, and 6 months, data included: week-long average home indoor concentration of PM ≤2.5 μm in aerodynamic diameter and PM ≤10 μm in aerodynamic diameter, dietary intake of omega-3 and omega-6 fatty acids, daiAmerican journal of respiratory and critical care medicineOmega-3 and Omega-6 Intake Modifies Asthma Severity and Response to Indoor Air Pollution in Children.PMC6580674KL2 TR001077P50 ES015903K24 ES021098T32 HL072748P50 ES018176P01 ES018176K23 ES029105Rice JKoehler KWoo HBrigham EPBose SSharma SRomero KHansel NNKoch AKolahdooz FHanson CMcCormack MVulcain TWu TDiette GfalseOmega-3 and Omega-6 Intake Modifies Asthma Severity and Response to Indoor Air Pollution in Children.<b>Rationale:</b> Higher indoor particulate matter (PM) concentrations are linked with increased asthma morbidity. Dietary intake of fatty acids, also linked with asthma outcomes, may influence this relationship. <b>Objectives:</b> To determine the relationship between omega-3 and omega-6 fatty acid intake and pediatric asthma morbidity, and the association between fatty acid intake and strength of indoor, PM-related asthma symptoms, albuterol use, and systemic inflammation. <b>Methods:</b> Analyses included 135 children with asthma enrolled in the AsthmaDIET Study. At baseline, 3 months, and 6 months, data included: week-long average home indoor concentration of PM ≤2.5 μm in aerodynamic diameter and PM ≤10 μm in aerodynamic diameter, dietary intake of omega-3 and omega-6 fatty acids, dai2019-01-01T00:00:00Z2019 Jun2025-04-19T10:43:18.48Z2022-02-09T15:01:17.267ZS-EPMC65806743092207710.1164/rccm.201808-1474OC10.1164/rccm.201808-1474oc