{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ewing LE"],"funding":["NIGMS NIH HHS"],"pagination":["93-99"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6581619"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["96(1)"],"pubmed_abstract":["<b>Purpose:</b> Growing rates of metabolic syndrome and associated obesity warrant the development of appropriate animal models for better understanding of how those conditions may affect sensitivity to IR exposure.<b>Materials and methods:</b> We subjected male NZO/HlLtJ mice, a strain prone to spontaneous obesity and diabetes, to 0, 5.5, 6.37, 7.4 or 8.5 Gy (<sup>137</sup>Cs) of total body irradiation (TBI). Mice were monitored for 30 days, after which proximal jejunum and colon tissues were collected for further histological and molecular analysis.<b>Results:</b> Obese NZO/HlLtJ male mice are characterized by their lower sensitivity to IR at doses of 6.37 Gy and under, compared to other strains. Further escalation of the dose, however, results in a steep survival curve, reaching LD<sub>"],"journal":["International journal of radiation biology"],"pubmed_title":["NZO/HlLtJ as a novel model for the studies on the role of metabolic syndrome in acute radiation toxicity."],"pmcid":["PMC6581619"],"funding_grant_id":["P20 GM109005"],"pubmed_authors":["Miousse IR","Pathak R","Skinner CM","Kosanke S","Hauer-Jensen M","Koturbash I","Ewing LE","Boerma M"],"additional_accession":[]},"is_claimable":false,"name":"NZO/HlLtJ as a novel model for the studies on the role of metabolic syndrome in acute radiation toxicity.","description":"<b>Purpose:</b> Growing rates of metabolic syndrome and associated obesity warrant the development of appropriate animal models for better understanding of how those conditions may affect sensitivity to IR exposure.<b>Materials and methods:</b> We subjected male NZO/HlLtJ mice, a strain prone to spontaneous obesity and diabetes, to 0, 5.5, 6.37, 7.4 or 8.5 Gy (<sup>137</sup>Cs) of total body irradiation (TBI). Mice were monitored for 30 days, after which proximal jejunum and colon tissues were collected for further histological and molecular analysis.<b>Results:</b> Obese NZO/HlLtJ male mice are characterized by their lower sensitivity to IR at doses of 6.37 Gy and under, compared to other strains. Further escalation of the dose, however, results in a steep survival curve, reaching LD<sub>","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jan","modification":"2025-04-29T10:35:11.777Z","creation":"2021-02-20T17:17:24Z"},"accession":"S-EPMC6581619","cross_references":{"pubmed":["30561233"],"doi":["10.1080/09553002.2018.1547437"]}}