biostudies-literatureEwing LENIGMS NIH HHS93-99https://www.ebi.ac.uk/biostudies/studies/S-EPMC6581619biostudies-literatureUnknown96(1)<b>Purpose:</b> Growing rates of metabolic syndrome and associated obesity warrant the development of appropriate animal models for better understanding of how those conditions may affect sensitivity to IR exposure.<b>Materials and methods:</b> We subjected male NZO/HlLtJ mice, a strain prone to spontaneous obesity and diabetes, to 0, 5.5, 6.37, 7.4 or 8.5 Gy (¹³⁷Cs) of total body irradiation (TBI). Mice were monitored for 30 days, after which proximal jejunum and colon tissues were collected for further histological and molecular analysis.<b>Results:</b> Obese NZO/HlLtJ male mice are characterized by their lower sensitivity to IR at doses of 6.37 Gy and under, compared to other strains. Further escalation of the dose, however, results in a steep survival curve, reaching LD<sub>International journal of radiation biologyNZO/HlLtJ as a novel model for the studies on the role of metabolic syndrome in acute radiation toxicity.PMC6581619P20 GM109005Miousse IRPathak RSkinner CMKosanke SHauer-Jensen MKoturbash IEwing LEBoerma MfalseNZO/HlLtJ as a novel model for the studies on the role of metabolic syndrome in acute radiation toxicity.<b>Purpose:</b> Growing rates of metabolic syndrome and associated obesity warrant the development of appropriate animal models for better understanding of how those conditions may affect sensitivity to IR exposure.<b>Materials and methods:</b> We subjected male NZO/HlLtJ mice, a strain prone to spontaneous obesity and diabetes, to 0, 5.5, 6.37, 7.4 or 8.5 Gy (¹³⁷Cs) of total body irradiation (TBI). Mice were monitored for 30 days, after which proximal jejunum and colon tissues were collected for further histological and molecular analysis.<b>Results:</b> Obese NZO/HlLtJ male mice are characterized by their lower sensitivity to IR at doses of 6.37 Gy and under, compared to other strains. Further escalation of the dose, however, results in a steep survival curve, reaching LD<sub>2020-01-01T00:00:00Z2020 Jan2025-04-29T10:35:11.777Z2021-02-20T17:17:24ZS-EPMC65816193056123310.1080/09553002.2018.1547437