{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10"],"submitter":["Anello M"],"funding":["Consejo Nacional de Investigaciones Científicas y Técnicas"],"pubmed_abstract":["Tyrosinase, encoded by <i>TYR</i> gene, is an enzyme that plays a major role in mammalian pigmentation. It catalyzes the oxidation of L-dihydroxy-phenylalanine (DOPA) to DOPA quinone, a precursor of both types of melanin: eumelanin and pheomelanin. <i>TYR</i> is commonly known as the <i>albino</i> locus since mutations in this gene result in albinism in several species. However, many other <i>TYR</i> mutations have been found to cause diluted phenotypes, like the Himalayan or chinchilla phenotypes in mice. The llama (<i>Lama glama</i>) presents a wide variety of coat colors ranging from non-diluted phenotypes (eumelanic and pheomelanic), through different degrees of dilution, to white. To investigate the possible contribution of <i>TYR</i> gene to coat color variation in llamas, we sequenc"],"journal":["Frontiers in genetics"],"pagination":["568"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6582663"],"repository":["biostudies-literature"],"pubmed_title":["<i>TYR</i> Gene in Llamas: Polymorphisms and Expression Study in Different Color Phenotypes."],"pmcid":["PMC6582663"],"pubmed_authors":["Vidal-Rioja L","Anello M","Fernandez E","Daverio MS","Di Rocco F"],"additional_accession":[]},"is_claimable":false,"name":"<i>TYR</i> Gene in Llamas: Polymorphisms and Expression Study in Different Color Phenotypes.","description":"Tyrosinase, encoded by <i>TYR</i> gene, is an enzyme that plays a major role in mammalian pigmentation. It catalyzes the oxidation of L-dihydroxy-phenylalanine (DOPA) to DOPA quinone, a precursor of both types of melanin: eumelanin and pheomelanin. <i>TYR</i> is commonly known as the <i>albino</i> locus since mutations in this gene result in albinism in several species. However, many other <i>TYR</i> mutations have been found to cause diluted phenotypes, like the Himalayan or chinchilla phenotypes in mice. The llama (<i>Lama glama</i>) presents a wide variety of coat colors ranging from non-diluted phenotypes (eumelanic and pheomelanic), through different degrees of dilution, to white. To investigate the possible contribution of <i>TYR</i> gene to coat color variation in llamas, we sequenc","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019","modification":"2026-04-08T06:08:52.643Z","creation":"2025-05-29T15:59:49.069Z"},"accession":"S-EPMC6582663","cross_references":{"pubmed":["31249599"],"doi":["10.3389/fgene.2019.00568"]}}