biostudies-literatureUnknown10Anello MConsejo Nacional de Investigaciones Científicas y TécnicasTyrosinase, encoded by <i>TYR</i> gene, is an enzyme that plays a major role in mammalian pigmentation. It catalyzes the oxidation of L-dihydroxy-phenylalanine (DOPA) to DOPA quinone, a precursor of both types of melanin: eumelanin and pheomelanin. <i>TYR</i> is commonly known as the <i>albino</i> locus since mutations in this gene result in albinism in several species. However, many other <i>TYR</i> mutations have been found to cause diluted phenotypes, like the Himalayan or chinchilla phenotypes in mice. The llama (<i>Lama glama</i>) presents a wide variety of coat colors ranging from non-diluted phenotypes (eumelanic and pheomelanic), through different degrees of dilution, to white. To investigate the possible contribution of <i>TYR</i> gene to coat color variation in llamas, we sequencFrontiers in genetics568https://www.ebi.ac.uk/biostudies/studies/S-EPMC6582663biostudies-literature<i>TYR</i> Gene in Llamas: Polymorphisms and Expression Study in Different Color Phenotypes.PMC6582663Vidal-Rioja LAnello MFernandez EDaverio MSDi Rocco Ffalse<i>TYR</i> Gene in Llamas: Polymorphisms and Expression Study in Different Color Phenotypes.Tyrosinase, encoded by <i>TYR</i> gene, is an enzyme that plays a major role in mammalian pigmentation. It catalyzes the oxidation of L-dihydroxy-phenylalanine (DOPA) to DOPA quinone, a precursor of both types of melanin: eumelanin and pheomelanin. <i>TYR</i> is commonly known as the <i>albino</i> locus since mutations in this gene result in albinism in several species. However, many other <i>TYR</i> mutations have been found to cause diluted phenotypes, like the Himalayan or chinchilla phenotypes in mice. The llama (<i>Lama glama</i>) presents a wide variety of coat colors ranging from non-diluted phenotypes (eumelanic and pheomelanic), through different degrees of dilution, to white. To investigate the possible contribution of <i>TYR</i> gene to coat color variation in llamas, we sequenc2019-01-01T00:00:00Z20192026-04-08T06:08:52.643Z2025-05-29T15:59:49.069ZS-EPMC65826633124959910.3389/fgene.2019.00568