biostudies-literatureKatanga JDanish International Development Agencye0218559https://www.ebi.ac.uk/biostudies/studies/S-EPMC6583973biostudies-literatureUnknown14(6)<h4>Objective</h4>To examine the test performance of careHPV, Hybrid Capture2 (HC2) and visual inspection with acetic acid (VIA) for detection of cytologically diagnosed high-grade cervical lesions or cancer (HSIL+).<h4>Design</h4>Cross-sectional study.<h4>Setting</h4>Ocean Road Cancer Institute (ORCI) and Kilimanjaro Christian Medical Center (KCMC), Tanzania.<h4>Population</h4>Women attending routine cervical cancer screening.<h4>Method</h4>We enrolled 4080 women (25-60 years) in the study. The women were interviewed on lifestyle habits, and tested for HIV. A cervical specimen for careHPV testing (performed at ORCI and KCMC), and a liquid-based cytology sample for HPV DNA detection using HC2 (performed at Tuebingen University Hospital, Germany) and for cytology assessment (performed at VePloS onePerformance of careHPV, hybrid capture 2 and visual inspection with acetic acid for detection of high-grade cervical lesion in Tanzania: A cross-sectional study.PMC658397314-TAN-P02Manongi RWaldstrom MPembe ABMwaiselage JRasch VIftner TKatanga JWu CSKjaer SKfalsePerformance of careHPV, hybrid capture 2 and visual inspection with acetic acid for detection of high-grade cervical lesion in Tanzania: A cross-sectional study.<h4>Objective</h4>To examine the test performance of careHPV, Hybrid Capture2 (HC2) and visual inspection with acetic acid (VIA) for detection of cytologically diagnosed high-grade cervical lesions or cancer (HSIL+).<h4>Design</h4>Cross-sectional study.<h4>Setting</h4>Ocean Road Cancer Institute (ORCI) and Kilimanjaro Christian Medical Center (KCMC), Tanzania.<h4>Population</h4>Women attending routine cervical cancer screening.<h4>Method</h4>We enrolled 4080 women (25-60 years) in the study. The women were interviewed on lifestyle habits, and tested for HIV. A cervical specimen for careHPV testing (performed at ORCI and KCMC), and a liquid-based cytology sample for HPV DNA detection using HC2 (performed at Tuebingen University Hospital, Germany) and for cytology assessment (performed at Ve2019-01-01T00:00:00Z20192025-05-29T21:05:11.616Z2025-05-29T21:05:11.616ZS-EPMC65839733121633310.1371/journal.pone.0218559