biostudies-literatureScully RRNASA | Johnson Space CenterNASA Human Research Program17https://www.ebi.ac.uk/biostudies/studies/S-EPMC6584569biostudies-literatureUnknown5Acute exposure to carbon dioxide (CO₂) concentrations below those found on the International Space Station are reported to deteriorate complex decision-making. Effective decision-making is critical to human spaceflight, especially during an emergency response. Therefore, effects of acutely elevated CO₂ on decision-making competency and various cognitive domains were assessed in astronaut-like subjects by the <i>Strategic Management Simulation</i> (SMS) and <i>Cognition</i> test batteries. The double-blind cross-over study included 22 participants at the Johnson Space Center randomly assigned to one of four groups. Each group was exposed to a different sequence of four concentrations of CO₂ (600, 1200, 2500, 5000 ppm). Subjects performed <i>Cognition</i> befNPJ microgravityEffects of acute exposures to carbon dioxide on decision making and cognition in astronaut-like subjects.PMC6584569NNX14AH98GNasrini JGur RCSatish UBasner MLam CWAlexander DJScully RRHermosillo EMoore TRyder VEfalseEffects of acute exposures to carbon dioxide on decision making and cognition in astronaut-like subjects.Acute exposure to carbon dioxide (CO₂) concentrations below those found on the International Space Station are reported to deteriorate complex decision-making. Effective decision-making is critical to human spaceflight, especially during an emergency response. Therefore, effects of acutely elevated CO₂ on decision-making competency and various cognitive domains were assessed in astronaut-like subjects by the <i>Strategic Management Simulation</i> (SMS) and <i>Cognition</i> test batteries. The double-blind cross-over study included 22 participants at the Johnson Space Center randomly assigned to one of four groups. Each group was exposed to a different sequence of four concentrations of CO₂ (600, 1200, 2500, 5000 ppm). Subjects performed <i>Cognition</i> bef2019-01-01T00:00:00Z20192025-05-29T21:06:26.458Z2025-05-29T21:06:26.458ZS-EPMC65845693124023910.1038/s41526-019-0071-6