{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(11)"],"submitter":["Chan YH"],"pubmed_abstract":["Background Rheumatic diseases are related to both abnormal bone turnover and atherogenesis, but a mechanistic link was missing. Methods and Results We investigated the effect of cumulative rheumatic inflammation ( CRI ) on risk of coronary calcification in a retrospective cohort of 145 rheumatoid arthritis patients. A time-adjusted aggregate CRI score was derived by conglomerating all quarterly biomarker encounters of serum C-reactive protein over 60 months immediately preceding computed tomography coronary angiography. Flow cytometry was performed to measure the osteocalcin-positive ( OCN <sup>+</sup>) CD 34<sup>+</sup> KDR <sup>+</sup> and OCN <sup>+</sup> CD 34<sup>+</sup> circulating endothelial progenitor cells ( EPCs ). Conventional early circulating EPCs CD 34<sup>+</sup> CD 133<sup"],"journal":["Journal of the American Heart Association"],"pagination":["e011540"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6585350"],"repository":["biostudies-literature"],"pubmed_title":["Cumulative Rheumatic Inflammation Modulates the Bone-Vascular Axis and Risk of Coronary Calcification."],"pmcid":["PMC6585350"],"pubmed_authors":["Tse HF","Lai K","Yiu KH","Ngai MC","Zhen Z","Lau CS","Yu YJ","Wu MZ","Ho LM","Chung HY","Cheung T","Chen Y","Chan YH"],"additional_accession":[]},"is_claimable":false,"name":"Cumulative Rheumatic Inflammation Modulates the Bone-Vascular Axis and Risk of Coronary Calcification.","description":"Background Rheumatic diseases are related to both abnormal bone turnover and atherogenesis, but a mechanistic link was missing. Methods and Results We investigated the effect of cumulative rheumatic inflammation ( CRI ) on risk of coronary calcification in a retrospective cohort of 145 rheumatoid arthritis patients. A time-adjusted aggregate CRI score was derived by conglomerating all quarterly biomarker encounters of serum C-reactive protein over 60 months immediately preceding computed tomography coronary angiography. Flow cytometry was performed to measure the osteocalcin-positive ( OCN <sup>+</sup>) CD 34<sup>+</sup> KDR <sup>+</sup> and OCN <sup>+</sup> CD 34<sup>+</sup> circulating endothelial progenitor cells ( EPCs ). Conventional early circulating EPCs CD 34<sup>+</sup> CD 133<sup","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Jun","modification":"2025-04-21T22:15:12.86Z","creation":"2019-07-24T07:23:57Z"},"accession":"S-EPMC6585350","cross_references":{"pubmed":["31130038"],"doi":["10.1161/JAHA.118.011540"]}}