{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Duc C"],"funding":["ARC","University of Georgia Research Foundation","IDEX-ISITE","Agence National de la Recherche"],"pagination":["127"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6587276"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(1)"],"pubmed_abstract":["<h4>Background</h4>For species survival, the germline must faithfully transmit genetic information to the progeny. Transposable elements (TEs) constitute a significant threat to genome stability due to their mobility. In the metazoan germline, their mobilization is limited by a class of small RNAs called PIWI-interacting RNAs (piRNAs) produced by dedicated genomic loci called piRNA clusters. Although the piRNA pathway is an adaptive genomic immunity system, it remains unclear how the germline gains protection from a new transposon invasion.<h4>Results</h4>To address this question, we analyze Drosophila melanogaster lines harboring a deletion within flamenco, a major piRNA cluster specifically expressed in somatic follicular cells. This deletion leads to derepression of the retrotransposon "],"journal":["Genome biology"],"pubmed_title":["Trapping a somatic endogenous retrovirus into a germline piRNA cluster immunizes the germline against further invasion."],"pmcid":["PMC6587276"],"funding_grant_id":["16-IDEX-0001","ANR-EpiTET"],"pubmed_authors":["Vaury C","Duc C","Mouniee N","Yoth M","Bergman CM","Jensen S","Brasset E"],"additional_accession":[]},"is_claimable":false,"name":"Trapping a somatic endogenous retrovirus into a germline piRNA cluster immunizes the germline against further invasion.","description":"<h4>Background</h4>For species survival, the germline must faithfully transmit genetic information to the progeny. Transposable elements (TEs) constitute a significant threat to genome stability due to their mobility. In the metazoan germline, their mobilization is limited by a class of small RNAs called PIWI-interacting RNAs (piRNAs) produced by dedicated genomic loci called piRNA clusters. Although the piRNA pathway is an adaptive genomic immunity system, it remains unclear how the germline gains protection from a new transposon invasion.<h4>Results</h4>To address this question, we analyze Drosophila melanogaster lines harboring a deletion within flamenco, a major piRNA cluster specifically expressed in somatic follicular cells. This deletion leads to derepression of the retrotransposon ","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Jun","modification":"2025-04-04T18:58:00.302Z","creation":"2019-07-24T07:25:14Z"},"accession":"S-EPMC6587276","cross_references":{"pubmed":["31227013"],"doi":["10.1186/s13059-019-1736-x"]}}