{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["He W"],"funding":["Guangzhou and Guangdong/Guangzhou Science and Technology Planning Program","Natural Science Foundation of Guangdong Province","National Natural Science Foundation of China"],"pagination":["1421-1431"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6587450"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["144(6)"],"pubmed_abstract":["Gestational choriocarcinoma (GC) is a highly aggressive tumor. In our study, we systematically investigated EpCAM/CD147 expression characteristics in patients with GC and assessed the role of circulating tumor cells (CTCs) in predicting chemotherapy response and disease progression. GC tissues were positive for either epithelial cellular adhesion molecule (EpCAM) or CD147, and all samples exhibited strong human chorionic gonadotropin (HCG) expression. Among all the recruited patients (n = 115), 103 had at least 1 CTC in a 7.5-mL peripheral blood sample, and the percentage of patients with ≥4 CTCs in a particular FIGO stage group increased with a higher FIGO stage (p < 0.001). Furthermore, the pretreatment CTC count was related to tumor size (r = 0.225, p = 0.015) and the number of metastas"],"journal":["International journal of cancer"],"pubmed_title":["Clinical significance of circulating tumor cells in predicting disease progression and chemotherapy resistance in patients with gestational choriocarcinoma."],"pmcid":["PMC6587450"],"funding_grant_id":["2011B031800025","2012B031800115","16ykjc08","2013B02180021","2015ykzd07","2015A030313036","2011B031800025, S2012010008378, 2015A030313036 and","2015A","30900650, 81372501, 81572260 and 81773299","2015A020214010","2016A020215055","S2012010008378","2014J4100132","201704020094"],"pubmed_authors":["Liu J","Cao J","Wang C","Zhang H","Sun C","Wang H","Shen H","Jiang N","Wang J","Wang L","Jiang W","Sun S","Ke Z","Chen Y","Chen X","Xu M","Sun Y","Li M","Hou M","Zeng C","He S","He W","Zhang Y","Cui Y","Lin M"],"additional_accession":[]},"is_claimable":false,"name":"Clinical significance of circulating tumor cells in predicting disease progression and chemotherapy resistance in patients with gestational choriocarcinoma.","description":"Gestational choriocarcinoma (GC) is a highly aggressive tumor. In our study, we systematically investigated EpCAM/CD147 expression characteristics in patients with GC and assessed the role of circulating tumor cells (CTCs) in predicting chemotherapy response and disease progression. GC tissues were positive for either epithelial cellular adhesion molecule (EpCAM) or CD147, and all samples exhibited strong human chorionic gonadotropin (HCG) expression. Among all the recruited patients (n = 115), 103 had at least 1 CTC in a 7.5-mL peripheral blood sample, and the percentage of patients with ≥4 CTCs in a particular FIGO stage group increased with a higher FIGO stage (p < 0.001). Furthermore, the pretreatment CTC count was related to tumor size (r = 0.225, p = 0.015) and the number of metastas","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Mar","modification":"2025-04-22T00:11:32.758Z","creation":"2019-07-24T07:25:20Z"},"accession":"S-EPMC6587450","cross_references":{"pubmed":["30070688"],"doi":["10.1002/ijc.31742"]}}