{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9"],"submitter":["Telatin V"],"pubmed_abstract":["Chronic HCV infection is characterized by several immunological alterations, such as the accumulation of suppressor cells and of hyperactivated T lymphocytes. However, it is unclear whether direct-acting antiviral (DAA)-mediated HCV clearance restores immune dysfunctions. We performed a phenotypic characterization by flow cytometry of different immune cell subsets, including monocytic myeloid-derived suppressor cells (M-MDSCs) and T lymphocytes in 168 patients with persistent HCV infection not treated, under DAA therapies and sustained virological responders. Chronic HCV infection prompted the accumulation of M-MDSCs independently of patient and clinical characteristics, and altered their metabolic properties. HCV RNA was undetectable in the majority of patients just after few weeks of DAA"],"journal":["Frontiers in cellular and infection microbiology"],"pagination":["190"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6588015"],"repository":["biostudies-literature"],"pubmed_title":["In Chronic Hepatitis C Infection, Myeloid-Derived Suppressor Cell Accumulation and T Cell Dysfunctions Revert Partially and Late After Successful Direct-Acting Antiviral Treatment."],"pmcid":["PMC6588015"],"pubmed_authors":["Menegotto N","Barbaro F","Erne E","Nicoli F","Castelli E","Frasson C","Palu G","Caputo A","Telatin V"],"additional_accession":[]},"is_claimable":false,"name":"In Chronic Hepatitis C Infection, Myeloid-Derived Suppressor Cell Accumulation and T Cell Dysfunctions Revert Partially and Late After Successful Direct-Acting Antiviral Treatment.","description":"Chronic HCV infection is characterized by several immunological alterations, such as the accumulation of suppressor cells and of hyperactivated T lymphocytes. However, it is unclear whether direct-acting antiviral (DAA)-mediated HCV clearance restores immune dysfunctions. We performed a phenotypic characterization by flow cytometry of different immune cell subsets, including monocytic myeloid-derived suppressor cells (M-MDSCs) and T lymphocytes in 168 patients with persistent HCV infection not treated, under DAA therapies and sustained virological responders. Chronic HCV infection prompted the accumulation of M-MDSCs independently of patient and clinical characteristics, and altered their metabolic properties. HCV RNA was undetectable in the majority of patients just after few weeks of DAA","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019","modification":"2025-04-22T00:07:35.811Z","creation":"2019-07-24T07:25:43Z"},"accession":"S-EPMC6588015","cross_references":{"pubmed":["31259160"],"doi":["10.3389/fcimb.2019.00190"]}}