biostudies-literatureHruba HVeterinární a Farmaceutická Univerzita Brno209https://www.ebi.ac.uk/biostudies/studies/S-EPMC6588855biostudies-literatureUnknown15(1)<h4>Background</h4>While commercial poultry and captive birds are exposed to antimicrobials through direct medication, environmental pollution may result in contamination of wild birds. Fluoroquinolones are commonly used medications to treat severe avian bacterial infections; however, their adverse effects on birds remain understudied. Here, we examine toxicity of enrofloxacin and marbofloxacin during the egg incubation period using the chicken (Gallus Gallus domesticus) as a model avian species. Laboratory tests were based on eggs injected with 1, 10 and 100 μg of fluoroquinolones per 1 g of egg weight prior to the start of incubation and monitoring of chick blood biochemistry, reproductive parameters and heart rate during incubation.<h4>Results</h4>Eggs treated with fluoroquinolones dispBMC veterinary researchReproductive toxicity of fluoroquinolones in birds.PMC6588855232/2017/FVHENemcova MPiacek VPikula JAnisimov NKovacova VHavelkova BVitula FKanova MSedlackova JBandouchova HHruba HHeger TAbdelsalam EEEfalseReproductive toxicity of fluoroquinolones in birds.<h4>Background</h4>While commercial poultry and captive birds are exposed to antimicrobials through direct medication, environmental pollution may result in contamination of wild birds. Fluoroquinolones are commonly used medications to treat severe avian bacterial infections; however, their adverse effects on birds remain understudied. Here, we examine toxicity of enrofloxacin and marbofloxacin during the egg incubation period using the chicken (Gallus Gallus domesticus) as a model avian species. Laboratory tests were based on eggs injected with 1, 10 and 100 μg of fluoroquinolones per 1 g of egg weight prior to the start of incubation and monitoring of chick blood biochemistry, reproductive parameters and heart rate during incubation.<h4>Results</h4>Eggs treated with fluoroquinolones disp2019-01-01T00:00:00Z2019 Jun2025-04-04T18:59:44.823Z2019-07-24T07:26:19ZS-EPMC65888553122698710.1186/s12917-019-1957-y