{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chen Y"],"funding":["Fundamental Research Funds for the Central Universities"],"pagination":["9490639"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6589239"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2019"],"pubmed_abstract":["A genome-wide association study (GWAS) identified that <i>BET1L</i> rs2280543 at chromosome 11p15.5 was a susceptibility loci of intracranial aneurysm (IA). Long noncoding RNA <i>H19</i>, located in this region, was reported to play a crucial role in the formation of IA. In this study, we aimed to examine whether <i>BET1L</i> rs2280543 and potentially functional polymorphisms in <i>H19</i> influence the risk of IA. A hospital-based case-control study was performed involving 542 IA patients and 588 age- and gender-matched controls. The <i>BET1L</i> rs2280543 and <i>H19</i> polymorphisms were genotyped using the TaqMan assay. The <i>BET1L</i> rs2280543 CT, CT/TT genotypes, and T allele were associated with an increased risk of IA (CT vs. CC, adjusted OR = 1.43, 95% CI: 1.08-1.90, <i>P</i> = "],"journal":["Disease markers"],"pubmed_title":["Replication of GWAS Loci Revealed an Increased Risk of <i>BET1L</i> and <i>H19</i> Polymorphisms with Intracranial Aneurysm."],"pmcid":["PMC6589239"],"funding_grant_id":["2017scu11038","2018SZ0216"],"pubmed_authors":["Chen Y","Sima X"],"additional_accession":[]},"is_claimable":false,"name":"Replication of GWAS Loci Revealed an Increased Risk of <i>BET1L</i> and <i>H19</i> Polymorphisms with Intracranial Aneurysm.","description":"A genome-wide association study (GWAS) identified that <i>BET1L</i> rs2280543 at chromosome 11p15.5 was a susceptibility loci of intracranial aneurysm (IA). Long noncoding RNA <i>H19</i>, located in this region, was reported to play a crucial role in the formation of IA. In this study, we aimed to examine whether <i>BET1L</i> rs2280543 and potentially functional polymorphisms in <i>H19</i> influence the risk of IA. A hospital-based case-control study was performed involving 542 IA patients and 588 age- and gender-matched controls. The <i>BET1L</i> rs2280543 and <i>H19</i> polymorphisms were genotyped using the TaqMan assay. The <i>BET1L</i> rs2280543 CT, CT/TT genotypes, and T allele were associated with an increased risk of IA (CT vs. CC, adjusted OR = 1.43, 95% CI: 1.08-1.90, <i>P</i> = ","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019","modification":"2025-04-05T16:24:04.841Z","creation":"2019-07-24T07:26:36Z"},"accession":"S-EPMC6589239","cross_references":{"pubmed":["31275455"],"doi":["10.1155/2019/9490639"]}}