biostudies-literatureChen YFundamental Research Funds for the Central Universities9490639https://www.ebi.ac.uk/biostudies/studies/S-EPMC6589239biostudies-literatureUnknown2019A genome-wide association study (GWAS) identified that <i>BET1L</i> rs2280543 at chromosome 11p15.5 was a susceptibility loci of intracranial aneurysm (IA). Long noncoding RNA <i>H19</i>, located in this region, was reported to play a crucial role in the formation of IA. In this study, we aimed to examine whether <i>BET1L</i> rs2280543 and potentially functional polymorphisms in <i>H19</i> influence the risk of IA. A hospital-based case-control study was performed involving 542 IA patients and 588 age- and gender-matched controls. The <i>BET1L</i> rs2280543 and <i>H19</i> polymorphisms were genotyped using the TaqMan assay. The <i>BET1L</i> rs2280543 CT, CT/TT genotypes, and T allele were associated with an increased risk of IA (CT vs. CC, adjusted OR = 1.43, 95% CI: 1.08-1.90, <i>P</i> = Disease markersReplication of GWAS Loci Revealed an Increased Risk of <i>BET1L</i> and <i>H19</i> Polymorphisms with Intracranial Aneurysm.PMC65892392017scu110382018SZ0216Chen YSima XfalseReplication of GWAS Loci Revealed an Increased Risk of <i>BET1L</i> and <i>H19</i> Polymorphisms with Intracranial Aneurysm.A genome-wide association study (GWAS) identified that <i>BET1L</i> rs2280543 at chromosome 11p15.5 was a susceptibility loci of intracranial aneurysm (IA). Long noncoding RNA <i>H19</i>, located in this region, was reported to play a crucial role in the formation of IA. In this study, we aimed to examine whether <i>BET1L</i> rs2280543 and potentially functional polymorphisms in <i>H19</i> influence the risk of IA. A hospital-based case-control study was performed involving 542 IA patients and 588 age- and gender-matched controls. The <i>BET1L</i> rs2280543 and <i>H19</i> polymorphisms were genotyped using the TaqMan assay. The <i>BET1L</i> rs2280543 CT, CT/TT genotypes, and T allele were associated with an increased risk of IA (CT vs. CC, adjusted OR = 1.43, 95% CI: 1.08-1.90, <i>P</i> = 2019-01-01T00:00:00Z20192025-04-05T16:24:04.841Z2019-07-24T07:26:36ZS-EPMC65892393127545510.1155/2019/9490639