{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kircanski K"],"funding":["Intramural NIH HHS","Intramural Research Program (IRP) of the National Institute of Mental Health, National Institutes of Health"],"pagination":["141-149"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6590706"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["118"],"pubmed_abstract":["Pediatric irritability is prevalent and impairing, yet little is known about its pathophysiology and treatment. In this article, we build on our and others' previous work to posit core mechanisms of irritability operating across the brain, behavior, and environment. Specifically, we propose proximal processes that surround the symptomatology of irritability and are potential targets for an exposure-based cognitive-behavioral therapy (CBT) for irritability that our group has developed. The heart of this model focuses on neurocognitive processes: youth's encoding of nonreward and threat stimuli, which involves prediction error signaling in the brain, and cognitive control in the context of frustration. Alterations in these processes are theorized to be central to chronic, severe irritability"],"journal":["Behaviour research and therapy"],"pubmed_title":["Exposure therapy for pediatric irritability: Theory and potential mechanisms."],"pmcid":["PMC6590706"],"funding_grant_id":["ZIA MH002786","ZIAMH002781","ZIA MH002781-17","Z99 MH999999","ZIAMH002786","ZIA MH002781","ZIA MH002786-17"],"pubmed_authors":["Averbeck BB","Craske MG","Pine DS","Kircanski K","Brotman MA","Leibenluft E"],"additional_accession":[]},"is_claimable":false,"name":"Exposure therapy for pediatric irritability: Theory and potential mechanisms.","description":"Pediatric irritability is prevalent and impairing, yet little is known about its pathophysiology and treatment. In this article, we build on our and others' previous work to posit core mechanisms of irritability operating across the brain, behavior, and environment. Specifically, we propose proximal processes that surround the symptomatology of irritability and are potential targets for an exposure-based cognitive-behavioral therapy (CBT) for irritability that our group has developed. The heart of this model focuses on neurocognitive processes: youth's encoding of nonreward and threat stimuli, which involves prediction error signaling in the brain, and cognitive control in the context of frustration. Alterations in these processes are theorized to be central to chronic, severe irritability","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Jul","modification":"2025-04-04T07:38:03.203Z","creation":"2020-07-05T07:08:56Z"},"accession":"S-EPMC6590706","cross_references":{"pubmed":["31085355"],"doi":["10.1016/j.brat.2019.04.007"]}}