{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["de Fatima A"],"funding":["Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico","BLRD VA","Office of Dietary Supplements","NCCIH NIH HHS","University of North Texas","National Center for Complementary and Integrative Health","U.S. Department of Veterans Affairs"],"pagination":["8222-8330"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6590917"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["4(5)"],"pubmed_abstract":["Bioactive dietary polyphenols have health benefits against a variety of disorders, but some benefits of polyphenols may be not directly related to them, but rather to their metabolites. Recently, we have identified the brain-available phenol glucuronide metabolite deoxyrhapontigenin-3-<i>O</i>-<i>β</i>-D-glucuronide (<b>5</b>) in perfused rat brains following sub-acute treatment with the stilbene resveratrol (<b>1</b>). However, the role of such a metabolite in the neuroprotective activity of resveratrol (<b>1</b>) is not understood, in part due to the non-commercial availability of <b>5</b> for performing biological evaluation in animal models of Alzheimer's disease or other neurological disorders. Here, we describe a concise chemical synthesis of deoxyrhapontigenin-3-<i>O</i>-<i>β</i>-D-"],"journal":["ACS omega"],"pubmed_title":["An Efficient Synthesis of Deoxyrhapontigenin-3-<i>O</i>-<i>β</i>-D-glucuronide, a Brain-targeted Derivative of Dietary Resveratrol, and its Precursor 4'-<i>O</i>-Me-Resveratrol."],"pmcid":["PMC6590917"],"funding_grant_id":["P50 AT008661-01","IK6 BX003785","204106/2017-6","P50 AT008661"],"pubmed_authors":["Docampo-Palacios M","Alvarez-Hernandez A","de Fatima A","Pasinetti GM","Dixon RA"],"additional_accession":[]},"is_claimable":false,"name":"An Efficient Synthesis of Deoxyrhapontigenin-3-<i>O</i>-<i>β</i>-D-glucuronide, a Brain-targeted Derivative of Dietary Resveratrol, and its Precursor 4'-<i>O</i>-Me-Resveratrol.","description":"Bioactive dietary polyphenols have health benefits against a variety of disorders, but some benefits of polyphenols may be not directly related to them, but rather to their metabolites. Recently, we have identified the brain-available phenol glucuronide metabolite deoxyrhapontigenin-3-<i>O</i>-<i>β</i>-D-glucuronide (<b>5</b>) in perfused rat brains following sub-acute treatment with the stilbene resveratrol (<b>1</b>). However, the role of such a metabolite in the neuroprotective activity of resveratrol (<b>1</b>) is not understood, in part due to the non-commercial availability of <b>5</b> for performing biological evaluation in animal models of Alzheimer's disease or other neurological disorders. Here, we describe a concise chemical synthesis of deoxyrhapontigenin-3-<i>O</i>-<i>β</i>-D-","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 May","modification":"2025-04-04T21:00:41.927Z","creation":"2019-07-24T07:27:22Z"},"accession":"S-EPMC6590917","cross_references":{"pubmed":["31236526"],"doi":["10.1021/acsomega.9b00722"]}}