{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["d'Almeida TC"],"funding":["Agence Nationale de la Recherche"],"pagination":["9160"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6591392"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(1)"],"pubmed_abstract":["Placental malaria has been associated with an immune tolerance phenomenon and a higher susceptibility to malaria infection during infancy. HLA-G is involved in fetal maternal immune tolerance by inhibiting maternal immunity. During infections HLA-G can be involved in immune escape of pathogens by creating a tolerogenic environment. Recent studies have shown an association between the risk of malaria and HLA-G at both genetic and protein levels. Moreover, women with placental malaria have a higher probability of giving birth to children exhibiting high sHLA-G, independently of their own level during pregnancy. Our aim was to explore the association between the level of maternal soluble HLA-G and the risk of malaria infection in their newborns. Here, 400 pregnant women and their children wer"],"journal":["Scientific reports"],"pubmed_title":["High level of soluble human leukocyte antigen (HLA)-G at beginning of pregnancy as predictor of risk of malaria during infancy."],"pmcid":["PMC6591392"],"funding_grant_id":["2010-PRSP-012 001"],"pubmed_authors":["Sadissou I","Rouas-Freiss N","Milet J","Gineau L","Moreau P","Pennetier C","Carosella E","Cottrell G","Donadi EA","Moutairou K","Sabbagh A","Moiroux N","Courtin D","Sagbohan M","Garcia A","Avokpaho E","Favier B","Baldet T","d'Almeida TC"],"additional_accession":[]},"is_claimable":false,"name":"High level of soluble human leukocyte antigen (HLA)-G at beginning of pregnancy as predictor of risk of malaria during infancy.","description":"Placental malaria has been associated with an immune tolerance phenomenon and a higher susceptibility to malaria infection during infancy. HLA-G is involved in fetal maternal immune tolerance by inhibiting maternal immunity. During infections HLA-G can be involved in immune escape of pathogens by creating a tolerogenic environment. Recent studies have shown an association between the risk of malaria and HLA-G at both genetic and protein levels. Moreover, women with placental malaria have a higher probability of giving birth to children exhibiting high sHLA-G, independently of their own level during pregnancy. Our aim was to explore the association between the level of maternal soluble HLA-G and the risk of malaria infection in their newborns. Here, 400 pregnant women and their children wer","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Jun","modification":"2025-05-31T22:24:34.021Z","creation":"2025-05-31T22:24:34.021Z"},"accession":"S-EPMC6591392","cross_references":{"pubmed":["31235762"],"doi":["10.1038/s41598-019-45688-w"]}}