biostudies-literatured'Almeida TCAgence Nationale de la Recherche9160https://www.ebi.ac.uk/biostudies/studies/S-EPMC6591392biostudies-literatureUnknown9(1)Placental malaria has been associated with an immune tolerance phenomenon and a higher susceptibility to malaria infection during infancy. HLA-G is involved in fetal maternal immune tolerance by inhibiting maternal immunity. During infections HLA-G can be involved in immune escape of pathogens by creating a tolerogenic environment. Recent studies have shown an association between the risk of malaria and HLA-G at both genetic and protein levels. Moreover, women with placental malaria have a higher probability of giving birth to children exhibiting high sHLA-G, independently of their own level during pregnancy. Our aim was to explore the association between the level of maternal soluble HLA-G and the risk of malaria infection in their newborns. Here, 400 pregnant women and their children werScientific reportsHigh level of soluble human leukocyte antigen (HLA)-G at beginning of pregnancy as predictor of risk of malaria during infancy.PMC65913922010-PRSP-012 001Sadissou IRouas-Freiss NMilet JGineau LMoreau PPennetier CCarosella ECottrell GDonadi EAMoutairou KSabbagh AMoiroux NCourtin DSagbohan MGarcia AAvokpaho EFavier BBaldet Td'Almeida TCfalseHigh level of soluble human leukocyte antigen (HLA)-G at beginning of pregnancy as predictor of risk of malaria during infancy.Placental malaria has been associated with an immune tolerance phenomenon and a higher susceptibility to malaria infection during infancy. HLA-G is involved in fetal maternal immune tolerance by inhibiting maternal immunity. During infections HLA-G can be involved in immune escape of pathogens by creating a tolerogenic environment. Recent studies have shown an association between the risk of malaria and HLA-G at both genetic and protein levels. Moreover, women with placental malaria have a higher probability of giving birth to children exhibiting high sHLA-G, independently of their own level during pregnancy. Our aim was to explore the association between the level of maternal soluble HLA-G and the risk of malaria infection in their newborns. Here, 400 pregnant women and their children wer2019-01-01T00:00:00Z2019 Jun2025-05-31T22:24:34.021Z2025-05-31T22:24:34.021ZS-EPMC65913923123576210.1038/s41598-019-45688-w