biostudies-literatureFlores-Ramirez GMinisterstvo školstva, vedy, výskumu a športu Slovenskej republikyResearch &amp; Development Operational Programme funded by the European Regional Development FundResearch & Development Operational Programme funded by the European Regional Development Fund318https://www.ebi.ac.uk/biostudies/studies/S-EPMC6591964biostudies-literatureUnknown12(1)<h4>Background</h4>Tick-borne rickettsial diseases are caused by pathogens acquired from hard ticks. In particular, Rickettsia slovaca, a zoonotic infectious bacterium causing tick-borne lymphadenopathy (TIBOLA), is transmitted by the vectors Dermacentor spp. that can be found all over Europe. Although recent studies point out the extreme complexity of bacteria-induced effects in these blood-feeding vectors, the knowledge of individual molecules involved in the preservation and transmission of the pathogen is still limited. System biology tools, including proteomics, may contribute greatly to the understanding of pathogen-tick-host interactions.<h4>Methods</h4>Herein, we performed a comparative proteomics study of the tick vector Dermacentor reticulatus that was experimentally infected witParasites & vectorsComparative proteomics of the vector Dermacentor reticulatus revealed differentially regulated proteins associated with pathogen transmission in response to laboratory infection with Rickettsia slovaca.PMC65919642/0052/192/0068/1726240220096Sallay BDanchenko MLakhneko OSpitalska EFlores-Ramirez GSkultety LfalseComparative proteomics of the vector Dermacentor reticulatus revealed differentially regulated proteins associated with pathogen transmission in response to laboratory infection with Rickettsia slovaca.<h4>Background</h4>Tick-borne rickettsial diseases are caused by pathogens acquired from hard ticks. In particular, Rickettsia slovaca, a zoonotic infectious bacterium causing tick-borne lymphadenopathy (TIBOLA), is transmitted by the vectors Dermacentor spp. that can be found all over Europe. Although recent studies point out the extreme complexity of bacteria-induced effects in these blood-feeding vectors, the knowledge of individual molecules involved in the preservation and transmission of the pathogen is still limited. System biology tools, including proteomics, may contribute greatly to the understanding of pathogen-tick-host interactions.<h4>Methods</h4>Herein, we performed a comparative proteomics study of the tick vector Dermacentor reticulatus that was experimentally infected wit2019-01-01T00:00:00Z2019 Jun2026-05-07T14:57:44.152Z2025-05-18T11:02:23.946ZS-EPMC65919643123491310.1186/s13071-019-3564-y