{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tran TTT"],"funding":["Association for Progressive Communications","Science Foundation Ireland","Food Institutional Research Measure","Department of Agriculture, Food and the Marine, Ireland","Sugar Research Australia","Biotechnology and Biological Sciences Research Council"],"pagination":["8221-8231"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6593891"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["33(7)"],"pubmed_abstract":["Apolipoprotein E (<i>APOE</i>) genotype is the strongest prevalent genetic risk factor for Alzheimer's disease (AD). Numerous studies have provided insights into the pathologic mechanisms. However, a comprehensive understanding of the impact of <i>APOE</i> genotype on microflora speciation and metabolism is completely lacking. In this study, we investigated the association between <i>APOE</i> genotype and the gut microbiome composition in human and <i>APOE</i>-targeted replacement (TR) transgenic mice. Fecal microbiota amplicon sequencing from matched individuals with different <i>APOE</i> genotypes revealed no significant differences in overall microbiota diversity in group-aggregated human <i>APOE</i> genotypes. However, several bacterial taxa showed significantly different relative abun"],"journal":["FASEB journal : official publication of the Federation of American Societies for Experimental Biology"],"pubmed_title":["&lt;i&gt;APOE&lt;/i&gt; genotype influences the gut microbiome structure and function in humans and mice: relevance for Alzheimer's disease pathophysiology."],"pmcid":["PMC6593891"],"funding_grant_id":["BBS/E/F/000PR10353","PRJNA533610","BBS/E/F/000PR10356","BBS/E/F/00044453","BB/M004449/1"],"pubmed_authors":["Corsini S","Tran TTT","Muller M","Minihane AM","Narbad A","O'Toole PW","Tejera N","Le Gall G","Hegarty C","Vauzour D","Kellingray L"],"additional_accession":[]},"is_claimable":false,"name":"&lt;i&gt;APOE&lt;/i&gt; genotype influences the gut microbiome structure and function in humans and mice: relevance for Alzheimer's disease pathophysiology.","description":"Apolipoprotein E (<i>APOE</i>) genotype is the strongest prevalent genetic risk factor for Alzheimer's disease (AD). Numerous studies have provided insights into the pathologic mechanisms. However, a comprehensive understanding of the impact of <i>APOE</i> genotype on microflora speciation and metabolism is completely lacking. In this study, we investigated the association between <i>APOE</i> genotype and the gut microbiome composition in human and <i>APOE</i>-targeted replacement (TR) transgenic mice. Fecal microbiota amplicon sequencing from matched individuals with different <i>APOE</i> genotypes revealed no significant differences in overall microbiota diversity in group-aggregated human <i>APOE</i> genotypes. However, several bacterial taxa showed significantly different relative abun","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Jul","modification":"2026-05-07T06:16:53.193Z","creation":"2019-07-24T07:29:06Z"},"accession":"S-EPMC6593891","cross_references":{"pubmed":["30958695"],"doi":["10.1096/fj.201900071R"]}}