biostudies-literatureTran TTTAssociation for Progressive CommunicationsScience Foundation IrelandFood Institutional Research MeasureDepartment of Agriculture, Food and the Marine, IrelandSugar Research AustraliaBiotechnology and Biological Sciences Research Council8221-8231https://www.ebi.ac.uk/biostudies/studies/S-EPMC6593891biostudies-literatureUnknown33(7)Apolipoprotein E (<i>APOE</i>) genotype is the strongest prevalent genetic risk factor for Alzheimer's disease (AD). Numerous studies have provided insights into the pathologic mechanisms. However, a comprehensive understanding of the impact of <i>APOE</i> genotype on microflora speciation and metabolism is completely lacking. In this study, we investigated the association between <i>APOE</i> genotype and the gut microbiome composition in human and <i>APOE</i>-targeted replacement (TR) transgenic mice. Fecal microbiota amplicon sequencing from matched individuals with different <i>APOE</i> genotypes revealed no significant differences in overall microbiota diversity in group-aggregated human <i>APOE</i> genotypes. However, several bacterial taxa showed significantly different relative abunFASEB journal : official publication of the Federation of American Societies for Experimental Biology<i>APOE</i> genotype influences the gut microbiome structure and function in humans and mice: relevance for Alzheimer's disease pathophysiology.PMC6593891BBS/E/F/000PR10353PRJNA533610BBS/E/F/000PR10356BBS/E/F/00044453BB/M004449/1Corsini STran TTTMuller MMinihane AMNarbad AO'Toole PWTejera NLe Gall GHegarty CVauzour DKellingray Lfalse<i>APOE</i> genotype influences the gut microbiome structure and function in humans and mice: relevance for Alzheimer's disease pathophysiology.Apolipoprotein E (<i>APOE</i>) genotype is the strongest prevalent genetic risk factor for Alzheimer's disease (AD). Numerous studies have provided insights into the pathologic mechanisms. However, a comprehensive understanding of the impact of <i>APOE</i> genotype on microflora speciation and metabolism is completely lacking. In this study, we investigated the association between <i>APOE</i> genotype and the gut microbiome composition in human and <i>APOE</i>-targeted replacement (TR) transgenic mice. Fecal microbiota amplicon sequencing from matched individuals with different <i>APOE</i> genotypes revealed no significant differences in overall microbiota diversity in group-aggregated human <i>APOE</i> genotypes. However, several bacterial taxa showed significantly different relative abun2019-01-01T00:00:00Z2019 Jul2026-05-07T06:16:53.193Z2019-07-24T07:29:06ZS-EPMC65938913095869510.1096/fj.201900071R