biostudies-literatureDas SNCATS NIH HHSNIH Common Fund Extracellular RNA Communication ProgramNIDA NIH HHSNIDDK NIH HHSNIA NIH HHSNHLBI NIH HHSNCI NIH HHSNINDS NIH HHSNIAMS NIH HHS231-242https://www.ebi.ac.uk/biostudies/studies/S-EPMC6601620biostudies-literatureUnknown177(2)The Extracellular RNA Communication Consortium (ERCC) was launched to accelerate progress in the new field of extracellular RNA (exRNA) biology and to establish whether exRNAs and their carriers, including extracellular vesicles (EVs), can mediate intercellular communication and be utilized for clinical applications. Phase 1 of the ERCC focused on exRNA/EV biogenesis and function, discovery of exRNA biomarkers, development of exRNA/EV-based therapeutics, and construction of a robust set of reference exRNA profiles for a variety of biofluids. Here, we present progress by ERCC investigators in these areas, and we discuss collaborative projects directed at development of robust methods for EV/exRNA isolation and analysis and tools for sharing and computational analysis of exRNA profiling dataCellThe Extracellular RNA Communication Consortium: Establishing Foundational Knowledge and Technologies for Extracellular RNA Research.PMC66016201UH2TR000928UH3 TR000933UH2 TR000880UH3 TR000931R01 NS019108U19 CA179513U19 CA1795121UH2TR000884U19 CA1795141UH2TR0009231UH2TR0008881UH2TR000921UH2 TR000914R01 HL1457211U19CA179564P30 DK0205721UH2TR000880UH2 TR0009181U19CA179563UH2 TR000875R01 DK1004491UH2TR000914UH3 TR0009431UH2TR0009181UH2TR000875UH3 TR000903UH3 TR000901UH3 TR000902U19 CA179564U19 CA179563UH3 TR000906UH2 TR0009011U01HL1264951U01HL126496UH2 TR0009031U01HL126497UH2 TR0009021U01HL126493K24 HL1370131U01HL126494UH2 TR000906R01 HL1289961U01HL126499UH2 TR0009431UH2TR0009061UH2TR000903UH3 TR000875UH3 TR0009141UH2TR000901UH3 TR0009181UH2TR0009021UH2TR000943P01 CA069246UH2 TR000933U01 HL126499U01 HL126497U01 HL126496U01 HL126495U01 HL126494U01 HL126493UH2 TR000931R01 AG0412321U54DA036134UH3 TR000884T32 AR059033UH3 TR000888UH3 TR000921UH2 TR000891UH2 TR0008901UH2TR000931U54 DA036134UH3 TR000923UH3 TR0009281UH2TR000933UH2 TR0009231U19CA1795131U19CA1795141UH2TR0008901U19CA1795121UH2TR000891UH2 TR000928UH2 TR000884UH3 TR000891UH2 TR000888UH2 TR000921UH3 TR000890Rao SJSood AKDatta AShah NKanlikilicer PAlsop EShah RAdelson PDGuo PMuthukumar TQuesenberry PJWong DTWBitzer MCarter BSPatel THunter CSchmittgen TDZhang BUrbanowicz KKFerrer MKaraszti RAKitchen RPatton JGArango JRanabothu SRozowsky JKwong RYPhelps MARodriguez-Aguayo CGandhi RWilliams ZMax KEARoth MEJackson ARGalas DJCoffey RJHochberg FKim HBogardus KAPeskind ERLee MWei ZMempel TRFranklin JLGoilav BYan IKErle DJHuentelman MKalani MYSTanriverdi KWeiner HLAvsaroglu SKMatin ACSubramanian SLAronin NYeri AXiao XTewari MBen-Dov IZBertram KVickers KCAnsel KMBlelloch RShedden KEtheridge AMondal DDiacovo TGKim YGiraldez MDShi JKim TKBalaj LMukamal KJSpetzler RL'Etoile NThistlethwaite WAdamidi CWeiss ZRVoinnet OWang KMilosavljevic ARosenzweig ATuschl TFreedman JEMateescu BPaul ASpengler RMCharest AGupta MHuang BMeyer CGaleev TLi JSakhanenko NAZhang HGLi FChen CCCourtright-Lim AWoodruff PGGerstein MBSaugstad JAAzizian ALi XPatel DJDeHoff PGhiran ICCalin GASabatine MSGarcia AGogakos TGould SJLucero RLevy SESuthanthiran MDas SWeaver AMRaffai RLGhai VBreakefield XOLopez-Berestein GSrinivasan STeng YChitnis TO'Donnell CJExtracellular RNA Communication ConsortiumMurillo ODAbdel-Mageed ABNickerson DAKrichevsky AMSopeyin AAkat KMQuinn JFHutchins EKhvorova APutterman CLaurent LCGoga AMcManus MTVan Keuren-Jensen KKraig RPfalseThe Extracellular RNA Communication Consortium: Establishing Foundational Knowledge and Technologies for Extracellular RNA Research.The Extracellular RNA Communication Consortium (ERCC) was launched to accelerate progress in the new field of extracellular RNA (exRNA) biology and to establish whether exRNAs and their carriers, including extracellular vesicles (EVs), can mediate intercellular communication and be utilized for clinical applications. Phase 1 of the ERCC focused on exRNA/EV biogenesis and function, discovery of exRNA biomarkers, development of exRNA/EV-based therapeutics, and construction of a robust set of reference exRNA profiles for a variety of biofluids. Here, we present progress by ERCC investigators in these areas, and we discuss collaborative projects directed at development of robust methods for EV/exRNA isolation and analysis and tools for sharing and computational analysis of exRNA profiling data2019-01-01T00:00:00Z2019 Apr2025-05-29T20:47:42.129Z2020-05-22T15:27:03ZS-EPMC66016203095166710.1016/j.cell.2019.03.023