biostudies-literatureLeiphrakpam PDU.S. Department of Health & Human Services | National Institutes of HealthNCI NIH HHSU.S. Department of Health & Human Services | National Institutes of Health (NIH)9665https://www.ebi.ac.uk/biostudies/studies/S-EPMC6609602biostudies-literatureUnknown9(1)Keratan sulfate (KS) is a sulfated linear polymer of N-acetyllactosamine. Proteoglycans carrying keratan sulfate epitopes were majorly observed in cornea, cartilage and brain; and mainly involved in embryonic development, cornea transparency, and wound healing process. Recently, expression of KS in cancer has been shown to be highly associated with advanced tumor grade and poor prognosis. Therefore, we aimed to identify the expression of KS epitope in human pancreatic cancer primary and metastatic tumor lesions. Immunohistochemical analysis of KS expression was performed on primary pancreatic tumors and metastatic tissues. We observed an increased expression of KS epitope on primary tumor tissues compared to uninvolved normal and tumor stroma; and is associated with worse overall survival.Scientific reportsRole of keratan sulfate expression in human pancreatic cancer malignancy.PMC6609602R50CA211462R01 CA208108P50 CA127297P30CA36727R50 CA211462U01CA210240R01CA208108-01A1P50CA127297Grandgenett PMLeiphrakpam PDSwanson BQiu FYu FRadhakrishnan PPatil PPRemmers NfalseRole of keratan sulfate expression in human pancreatic cancer malignancy.Keratan sulfate (KS) is a sulfated linear polymer of N-acetyllactosamine. Proteoglycans carrying keratan sulfate epitopes were majorly observed in cornea, cartilage and brain; and mainly involved in embryonic development, cornea transparency, and wound healing process. Recently, expression of KS in cancer has been shown to be highly associated with advanced tumor grade and poor prognosis. Therefore, we aimed to identify the expression of KS epitope in human pancreatic cancer primary and metastatic tumor lesions. Immunohistochemical analysis of KS expression was performed on primary pancreatic tumors and metastatic tissues. We observed an increased expression of KS epitope on primary tumor tissues compared to uninvolved normal and tumor stroma; and is associated with worse overall survival.2019-01-01T00:00:00Z2019 Jul2026-05-07T18:26:06.401Z2019-07-25T07:03:57ZS-EPMC66096023127330610.1038/s41598-019-46046-6