biostudies-literatureIto TMinistry of Health, Labour and WelfareResearch on Human Genome Tailor-made from the Ministry of Health, Labor, and Welfare of JapanFoundation for the Development of the CommunityJapan Society for the Promotion of Science2284-2295https://www.ebi.ac.uk/biostudies/studies/S-EPMC6609799biostudies-literatureUnknown110(7)Cell adhesion molecule-1 (CADM1) is a member of the immunoglobulin superfamily that functions as a tumor suppressor of lung tumors. We herein demonstrated that CADM1 interacts with Hippo pathway core kinases and enhances the phosphorylation of YAP1, and also that the membranous co-expression of CADM1 and LATS2 predicts a favorable prognosis in lung adenocarcinoma. CADM1 significantly repressed the saturation density elevated by YAP1 overexpression in NIH3T3 cells. CADM1 significantly promoted YAP1 phosphorylation on Ser 127 and downregulated YAP1 target gene expression at confluency in lung adenocarcinoma cell lines. Moreover, CADM1 was co-precipitated with multiple Hippo pathway components, including the core kinases MST1/2 and LATS1/2, suggesting the involvement of CADM1 in the regulatioCancer scienceCADM1 associates with Hippo pathway core kinases; membranous co-expression of CADM1 and LATS2 in lung tumors predicts good prognosis.PMC660979916K1814216K0867225290051254604322629308018H02634Tsuboi YSekido YMorikawa TTanaka IMurakami YIto TNakajima JMatsubara DFukayama MTakai DNiki TNakamura AfalseCADM1 associates with Hippo pathway core kinases; membranous co-expression of CADM1 and LATS2 in lung tumors predicts good prognosis.Cell adhesion molecule-1 (CADM1) is a member of the immunoglobulin superfamily that functions as a tumor suppressor of lung tumors. We herein demonstrated that CADM1 interacts with Hippo pathway core kinases and enhances the phosphorylation of YAP1, and also that the membranous co-expression of CADM1 and LATS2 predicts a favorable prognosis in lung adenocarcinoma. CADM1 significantly repressed the saturation density elevated by YAP1 overexpression in NIH3T3 cells. CADM1 significantly promoted YAP1 phosphorylation on Ser 127 and downregulated YAP1 target gene expression at confluency in lung adenocarcinoma cell lines. Moreover, CADM1 was co-precipitated with multiple Hippo pathway components, including the core kinases MST1/2 and LATS1/2, suggesting the involvement of CADM1 in the regulatio2019-01-01T00:00:00Z2019 Jul2026-05-07T14:45:22.417Z2025-05-29T22:09:25.007ZS-EPMC66097993106986910.1111/cas.14040