{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(6)"],"submitter":["Quintanilla I"],"pubmed_abstract":["<h4>Introduction</h4>Over the past 20 years, aberrant crypt foci (ACF) have emerged as potential precursors and biomarkers for colorectal cancer (CRC). However, data regarding their molecular pathogenesis, as well as their endoscopic and histological identification, remain inconsistent.<h4>Methods</h4>A wide cohort of ACF from 100 control subjects and 100 case patients, including patients with adenoma and CRC, were characterized for endoscopic, morphologic, and molecular features.<h4>Results</h4>We observed that among all the endoscopic features evaluated, only the number of large ACF correlated with CRC risk (P = 0.003), whereas the histological classification, as assessed by 2 different pathologists, was inconsistent and did not differ between control and case patients. Moreover, only a "],"journal":["Clinical and translational gastroenterology"],"pagination":["e00047"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6613864"],"repository":["biostudies-literature"],"pubmed_title":["Rectal Aberrant Crypt Foci in Humans Are Not Surrogate Markers for Colorectal Cancer Risk."],"pmcid":["PMC6613864"],"pubmed_authors":["Camps J","Alonso V","Balaguer F","Lopez-Ceron M","Quintanilla I","Jimeno M","Zabalza M","Castells A","Pellise M","Munoz J","Castellvi-Bel S","Cuatrecasas M","Rodriguez de Miguel C","Llach J","Moreira L"],"additional_accession":[]},"is_claimable":false,"name":"Rectal Aberrant Crypt Foci in Humans Are Not Surrogate Markers for Colorectal Cancer Risk.","description":"<h4>Introduction</h4>Over the past 20 years, aberrant crypt foci (ACF) have emerged as potential precursors and biomarkers for colorectal cancer (CRC). However, data regarding their molecular pathogenesis, as well as their endoscopic and histological identification, remain inconsistent.<h4>Methods</h4>A wide cohort of ACF from 100 control subjects and 100 case patients, including patients with adenoma and CRC, were characterized for endoscopic, morphologic, and molecular features.<h4>Results</h4>We observed that among all the endoscopic features evaluated, only the number of large ACF correlated with CRC risk (P = 0.003), whereas the histological classification, as assessed by 2 different pathologists, was inconsistent and did not differ between control and case patients. Moreover, only a ","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Jun","modification":"2025-04-21T19:42:23.405Z","creation":"2019-10-11T07:02:49Z"},"accession":"S-EPMC6613864","cross_references":{"pubmed":["31136360"],"doi":["10.14309/ctg.0000000000000047"]}}