biostudies-literatureUnknown7(1)Dama PBristol-Myers SquibbImmune checkpoint pathways active in Acute Myeloid Leukemia (AML) patients, especially during the course of remission induction chemotherapy, have not been well studied. Although dominant in mediating T cell dysfunction in cancer, it is now well-accepted that interruption of PD-1/PD-L1 axes alone does not always completely restore T cell function, indicating the involvement of additional negative regulatory pathways, such as TIM-3/Gal-9, in promoting T cell exhaustion.Here, we characterized these pathways in AML patients enrolled in a phase I dose escalation trial that combined Selinexor, a Selective Inhibitor of Nuclear Export (SINE), with high-dose cytarabine (HiDAC) and mitoxantrone (Mito) (NCT02573363) as induction therapy.To monitor changes in expression of immune checkpoint receptorsJournal for immunotherapy of cancer175https://www.ebi.ac.uk/biostudies/studies/S-EPMC6621946biostudies-literatureGal9/Tim-3 expression level is higher in AML patients who fail chemotherapy.PMC6621946Kline JLiu HDama PTang MFulton NfalseGal9/Tim-3 expression level is higher in AML patients who fail chemotherapy.Immune checkpoint pathways active in Acute Myeloid Leukemia (AML) patients, especially during the course of remission induction chemotherapy, have not been well studied. Although dominant in mediating T cell dysfunction in cancer, it is now well-accepted that interruption of PD-1/PD-L1 axes alone does not always completely restore T cell function, indicating the involvement of additional negative regulatory pathways, such as TIM-3/Gal-9, in promoting T cell exhaustion.Here, we characterized these pathways in AML patients enrolled in a phase I dose escalation trial that combined Selinexor, a Selective Inhibitor of Nuclear Export (SINE), with high-dose cytarabine (HiDAC) and mitoxantrone (Mito) (NCT02573363) as induction therapy.To monitor changes in expression of immune checkpoint receptors2019-01-01T00:00:00Z2019 Jul2026-04-30T15:09:24.908Z2026-04-07T16:08:44.594ZS-EPMC66219463129198510.1186/s40425-019-0611-3