{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Haramati S"],"funding":["European Research Council"],"pagination":["14191-203"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6623664"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["31(40)"],"pubmed_abstract":["The etiology and pathophysiology of anxiety and mood disorders is linked to inappropriate regulation of the central stress response. To determine whether microRNAs have a functional role in the regulation of the stress response, we inactivated microRNA processing by a lentiviral-induced local ablation of the Dicer gene in the central amygdala (CeA) of adult mice. CeA Dicer ablation induced a robust increase in anxiety-like behavior, whereas manipulated neurons survive and appear to exhibit normal gross morphology in the time period examined. We also observed that acute stress in wild-type mice induced a differential expression profile of microRNAs in the amygdala. Bioinformatic analysis identified putative gene targets for these stress-responsive microRNAs, some of which are known to be as"],"journal":["The Journal of neuroscience : the official journal of the Society for Neuroscience"],"pubmed_title":["MicroRNA as repressors of stress-induced anxiety: the case of amygdalar miR-34."],"pmcid":["PMC6623664"],"funding_grant_id":["260463"],"pubmed_authors":["Haramati S","Chen A","Navon I","Gil S","Zwang R","Ezra-Nevo G","Issler O","Hornstein E"],"additional_accession":[]},"is_claimable":false,"name":"MicroRNA as repressors of stress-induced anxiety: the case of amygdalar miR-34.","description":"The etiology and pathophysiology of anxiety and mood disorders is linked to inappropriate regulation of the central stress response. To determine whether microRNAs have a functional role in the regulation of the stress response, we inactivated microRNA processing by a lentiviral-induced local ablation of the Dicer gene in the central amygdala (CeA) of adult mice. CeA Dicer ablation induced a robust increase in anxiety-like behavior, whereas manipulated neurons survive and appear to exhibit normal gross morphology in the time period examined. We also observed that acute stress in wild-type mice induced a differential expression profile of microRNAs in the amygdala. Bioinformatic analysis identified putative gene targets for these stress-responsive microRNAs, some of which are known to be as","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Oct","modification":"2025-04-04T15:02:23.784Z","creation":"2019-07-30T07:04:32Z"},"accession":"S-EPMC6623664","cross_references":{"pubmed":["21976504"],"doi":["10.1523/jneurosci.1673-11.2011","10.1523/JNEUROSCI.1673-11.2011"]}}