biostudies-literatureUnknown155(10)Nelson KC<h4>Importance</h4>To date, no concerted effort has been made to date to evaluate the literature on number-needed-to-biopsy (NNB) metrics, particularly to account for the differences in clinician type and melanoma prevalence in certain geographic locations.<h4>Objective</h4>To review and synthesize worldwide data for NNB for the diagnosis of cutaneous melanoma.<h4>Data source</h4>MEDLINE, Embase, and PubMed databases were searched for English-language articles published worldwide from January 1, 2000, to November 28, 2018.<h4>Study selection</h4>A total of 46 studies were included that addressed NNB for at least 3681 clinicians worldwide and included 455 496 biopsied tumors and 29 257 melanomas; primary care practitioner (PCP) data were only available from Australia.<h4>Data extraction andJAMA dermatology1167-1174https://www.ebi.ac.uk/biostudies/studies/S-EPMC6624799biostudies-literatureEvaluation of the Number-Needed-to-Biopsy Metric for the Diagnosis of Cutaneous Melanoma: A Systematic Review and Meta-analysis.PMC6624799Swetter SMCuriel-Lewandrowski CNelson KCSaboda KChen SCfalseEvaluation of the Number-Needed-to-Biopsy Metric for the Diagnosis of Cutaneous Melanoma: A Systematic Review and Meta-analysis.<h4>Importance</h4>To date, no concerted effort has been made to date to evaluate the literature on number-needed-to-biopsy (NNB) metrics, particularly to account for the differences in clinician type and melanoma prevalence in certain geographic locations.<h4>Objective</h4>To review and synthesize worldwide data for NNB for the diagnosis of cutaneous melanoma.<h4>Data source</h4>MEDLINE, Embase, and PubMed databases were searched for English-language articles published worldwide from January 1, 2000, to November 28, 2018.<h4>Study selection</h4>A total of 46 studies were included that addressed NNB for at least 3681 clinicians worldwide and included 455 496 biopsied tumors and 29 257 melanomas; primary care practitioner (PCP) data were only available from Australia.<h4>Data extraction and2019-01-01T00:00:00Z2019 Oct2025-04-26T15:49:42.063Z2025-04-06T14:58:05.823ZS-EPMC66247993129095810.1001/jamadermatol.2019.1514