{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Deng Z"],"funding":["Science and Technology Planning Project of Hunan Province","Natural Science Foundation of Hunan Province","National Natural Science Foundation of China"],"pagination":["217-224"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6625970"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17"],"pubmed_abstract":["Overexpression of endogenous H<sub>2</sub>S is one of the key characteristic in colon cancer. However, developing endogenous H<sub>2</sub>S-activated optical probes for specific diagnosis of colorectal cancer is rarely explored. Herein, an in situ H<sub>2</sub>S-activatable second near-infrared (NIR-II)-emitting nanoprobe based on Ag-chicken egg white (Ag-CEW) complex for intelligently lighting up colorectal cancer was explored. The designed Ag-CEW complex holds efficient NIR-II emission of 1,000-1,400 nm via endogenous H<sub>2</sub>S-induced in situ chemical reaction to form Ag<sub>2</sub>S quantum dots (QDs). After reaction, the designed Ag-CEW complex with high photo-stability and biocompatibility was successfully used for NIR-II imaging-guided specific visualization and precise locatio"],"journal":["iScience"],"pubmed_title":["Endogenous H<sub>2</sub>S-Triggered In Situ Synthesis of NIR-II-Emitting Nanoprobe for In Vivo Intelligently Lighting Up Colorectal Cancer."],"pmcid":["PMC6625970"],"funding_grant_id":["21671064","2019JJ10002","2017RS3031"],"pubmed_authors":["Liu H","Zeng S","Li Y","Hao J","Deng Z","Jiang M"],"additional_accession":[]},"is_claimable":false,"name":"Endogenous H<sub>2</sub>S-Triggered In Situ Synthesis of NIR-II-Emitting Nanoprobe for In Vivo Intelligently Lighting Up Colorectal Cancer.","description":"Overexpression of endogenous H<sub>2</sub>S is one of the key characteristic in colon cancer. However, developing endogenous H<sub>2</sub>S-activated optical probes for specific diagnosis of colorectal cancer is rarely explored. Herein, an in situ H<sub>2</sub>S-activatable second near-infrared (NIR-II)-emitting nanoprobe based on Ag-chicken egg white (Ag-CEW) complex for intelligently lighting up colorectal cancer was explored. The designed Ag-CEW complex holds efficient NIR-II emission of 1,000-1,400 nm via endogenous H<sub>2</sub>S-induced in situ chemical reaction to form Ag<sub>2</sub>S quantum dots (QDs). After reaction, the designed Ag-CEW complex with high photo-stability and biocompatibility was successfully used for NIR-II imaging-guided specific visualization and precise locatio","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Jul","modification":"2025-04-05T13:05:17.042Z","creation":"2019-07-30T07:05:20Z"},"accession":"S-EPMC6625970","cross_references":{"pubmed":["31301632"],"doi":["10.1016/j.isci.2019.06.034"]}}