{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rust R"],"funding":["University of Zurich"],"pagination":["14270-14279"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6628809"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["116(28)"],"pubmed_abstract":["Stroke is a major cause of serious disability due to the brain's limited capacity to regenerate damaged tissue and neuronal circuits. After ischemic injury, a multiphasic degenerative and inflammatory response is coupled with severely restricted vascular and neuronal repair, resulting in permanent functional deficits. Although clinical evidence indicates that revascularization of the ischemic brain regions is crucial for functional recovery, no therapeutics that promote angiogenesis after cerebral stroke are currently available. Besides vascular growth factors, guidance molecules have been identified to regulate aspects of angiogenesis in the central nervous system (CNS) and may provide targets for therapeutic angiogenesis. In this study, we demonstrate that genetic deletion of the neurite"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Nogo-A targeted therapy promotes vascular repair and functional recovery following stroke."],"pmcid":["PMC6628809"],"funding_grant_id":["FK-18-036"],"pubmed_authors":["Sartori AM","Rust R","Mulders G","Enzler A","Gronnert L","Gantner C","Meinhardt A","Siewert A","Limasale YDP","Schwab ME","Maurer MA","Werner C","Hofer AS","Weber RZ"],"additional_accession":[]},"is_claimable":false,"name":"Nogo-A targeted therapy promotes vascular repair and functional recovery following stroke.","description":"Stroke is a major cause of serious disability due to the brain's limited capacity to regenerate damaged tissue and neuronal circuits. After ischemic injury, a multiphasic degenerative and inflammatory response is coupled with severely restricted vascular and neuronal repair, resulting in permanent functional deficits. Although clinical evidence indicates that revascularization of the ischemic brain regions is crucial for functional recovery, no therapeutics that promote angiogenesis after cerebral stroke are currently available. Besides vascular growth factors, guidance molecules have been identified to regulate aspects of angiogenesis in the central nervous system (CNS) and may provide targets for therapeutic angiogenesis. In this study, we demonstrate that genetic deletion of the neurite","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Jul","modification":"2025-04-05T16:21:36.131Z","creation":"2025-04-05T16:21:36.131Z"},"accession":"S-EPMC6628809","cross_references":{"pubmed":["31235580"],"doi":["10.1073/pnas.1905309116"]}}