{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Moore C"],"funding":["NCRR NIH HHS","NIAID NIH HHS","NHLBI NIH HHS","Medical Research Council","National Institute for Health Research (NIHR)","NIAMS NIH HHS","NIGMS NIH HHS"],"pagination":["199-208"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6635791"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["200(2)"],"pubmed_abstract":["<b>Rationale:</b> Several common and rare genetic variants have been associated with idiopathic pulmonary fibrosis, a progressive fibrotic condition that is localized to the lung. <b>Objectives:</b> To develop an integrated understanding of the rare and common variants located in multiple loci that have been reported to contribute to the risk of disease. <b>Methods:</b> We performed deep targeted resequencing (3.69 Mb of DNA) in cases (<i>n</i> = 3,624) and control subjects (<i>n</i> = 4,442) across genes and regions previously associated with disease. We tested for associations between disease and <i>1</i>) individual common variants via logistic regression and <i>2</i>) groups of rare variants via sequence kernel association tests. <b>Measurements and Main Results:</b> Statistically sign"],"journal":["American journal of respiratory and critical care medicine"],"pubmed_title":["Resequencing Study Confirms That Host Defense and Cell Senescence Gene Variants Contribute to the Risk of Idiopathic Pulmonary Fibrosis."],"pmcid":["PMC6635791"],"funding_grant_id":["U54 GM104938","R01 HL130796","K08 HL130595","P01 HL092870","R01 HL097163","U19 AI082714","T32 HL007085","P30 AR073750","UL1 RR024975","RP-2017-08-ST2-014","P30 AR053483","R33 HL120770","MR/N005953/1"],"pubmed_authors":["Yang IV","Schwartz DA","Pardo A","Corte TJ","Miyazaki Y","Mathai SK","Bendstrup E","Kass DJ","Furusawa H","Brown KK","Poletti V","Rojas M","Armstong ME","Puppo F","Maher TM","Walker T","Russell P","Fingerlin TE","Isaksson HJ","Loyd JE","Schwarz MI","Ravaglia C","Inoue Y","Narumoto O","Kannengiesser C","Wilcox PG","Kim H","Lee J","Silverman EK","Tomassetti S","Gibson KF","Walts A","Borie R","Song JW","Maier LA","Kim DS","Sembrat J","de Andrade JA","Ma SF","Jenkins RG","Worboys AM","Molina-Molina M","Selman M","Baltic S","McElroy A","Luckhardt T","Prele C","Akagawa S","Patel NB","Bishop M","Ohta K","Beckman KB","Arai T","Moodley Y","Keane MP","Saini G","Donnelly SC","Strek ME","Okamoto T","Nathan SD","Hirose M","Markin CR","Porteous MK","Cardwell J","Pacheco KA","O'Riordan T","Saunders P","Laurent G","Suzukawa M","Rassl D","Noth I","Henry MT","Kreider ME","Cogan JD","Sundy JS","James JA","Braybrooke R","Li F","Montesi SB","Kulkarni T","Molyneaux PL","Cho MH","Vestal B","Crestani B","Machahua C","Wolters PJ","Podolanczuk AJ","Doran P","Bair C","Gudmundsson G","Swigris JJ","Mogulkoc N","Sterclova M","Guthridge JM","Kokturk N","Ryerson CJ","Venuto DC","Crapo JD","Bonella F","Parfrey H","Shea BS","Eickelberg O","Fernandez IE","Powers J","Blumhagen RZ","Kropski JA","Lederer DJ","Carbone RG","Aranda A","Hirani N","Nickerson DA","Steele MP","Glaspole I","Vasakova M","Woldehanna ML","Ji W","Zhang Y","Danchel V","Behr J","Moore C","Collard HR","Fiddler C","Poon AS"],"additional_accession":[]},"is_claimable":false,"name":"Resequencing Study Confirms That Host Defense and Cell Senescence Gene Variants Contribute to the Risk of Idiopathic Pulmonary Fibrosis.","description":"<b>Rationale:</b> Several common and rare genetic variants have been associated with idiopathic pulmonary fibrosis, a progressive fibrotic condition that is localized to the lung. <b>Objectives:</b> To develop an integrated understanding of the rare and common variants located in multiple loci that have been reported to contribute to the risk of disease. <b>Methods:</b> We performed deep targeted resequencing (3.69 Mb of DNA) in cases (<i>n</i> = 3,624) and control subjects (<i>n</i> = 4,442) across genes and regions previously associated with disease. We tested for associations between disease and <i>1</i>) individual common variants via logistic regression and <i>2</i>) groups of rare variants via sequence kernel association tests. <b>Measurements and Main Results:</b> Statistically sign","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Jul","modification":"2025-06-01T02:35:51.208Z","creation":"2025-06-01T02:35:51.208Z"},"accession":"S-EPMC6635791","cross_references":{"pubmed":["31034279"],"doi":["10.1164/rccm.201810-1891OC","10.1164/rccm.201810-1891oc"]}}