biostudies-literatureMoore CNCRR NIH HHSNIAID NIH HHSNHLBI NIH HHSMedical Research CouncilNational Institute for Health Research (NIHR)NIAMS NIH HHSNIGMS NIH HHS199-208https://www.ebi.ac.uk/biostudies/studies/S-EPMC6635791biostudies-literatureUnknown200(2)<b>Rationale:</b> Several common and rare genetic variants have been associated with idiopathic pulmonary fibrosis, a progressive fibrotic condition that is localized to the lung. <b>Objectives:</b> To develop an integrated understanding of the rare and common variants located in multiple loci that have been reported to contribute to the risk of disease. <b>Methods:</b> We performed deep targeted resequencing (3.69 Mb of DNA) in cases (<i>n</i> = 3,624) and control subjects (<i>n</i> = 4,442) across genes and regions previously associated with disease. We tested for associations between disease and <i>1</i>) individual common variants via logistic regression and <i>2</i>) groups of rare variants via sequence kernel association tests. <b>Measurements and Main Results:</b> Statistically signAmerican journal of respiratory and critical care medicineResequencing Study Confirms That Host Defense and Cell Senescence Gene Variants Contribute to the Risk of Idiopathic Pulmonary Fibrosis.PMC6635791U54 GM104938R01 HL130796K08 HL130595P01 HL092870R01 HL097163U19 AI082714T32 HL007085P30 AR073750UL1 RR024975RP-2017-08-ST2-014P30 AR053483R33 HL120770MR/N005953/1Yang IVSchwartz DAPardo ACorte TJMiyazaki YMathai SKBendstrup EKass DJFurusawa HBrown KKPoletti VRojas MArmstong MEPuppo FMaher TMWalker TRussell PFingerlin TEIsaksson HJLoyd JESchwarz MIRavaglia CInoue YNarumoto OKannengiesser CWilcox PGKim HLee JSilverman EKTomassetti SGibson KFWalts ABorie RSong JWMaier LAKim DSSembrat Jde Andrade JAMa SFJenkins RGWorboys AMMolina-Molina MSelman MBaltic SMcElroy ALuckhardt TPrele CAkagawa SPatel NBBishop MOhta KBeckman KBArai TMoodley YKeane MPSaini GDonnelly SCStrek MEOkamoto TNathan SDHirose MMarkin CRPorteous MKCardwell JPacheco KAO'Riordan TSaunders PLaurent GSuzukawa MRassl DNoth IHenry MTKreider MECogan JDSundy JSJames JABraybrooke RLi FMontesi SBKulkarni TMolyneaux PLCho MHVestal BCrestani BMachahua CWolters PJPodolanczuk AJDoran PBair CGudmundsson GSwigris JJMogulkoc NSterclova MGuthridge JMKokturk NRyerson CJVenuto DCCrapo JDBonella FParfrey HShea BSEickelberg OFernandez IEPowers JBlumhagen RZKropski JALederer DJCarbone RGAranda AHirani NNickerson DASteele MPGlaspole IVasakova MWoldehanna MLJi WZhang YDanchel VBehr JMoore CCollard HRFiddler CPoon ASfalseResequencing Study Confirms That Host Defense and Cell Senescence Gene Variants Contribute to the Risk of Idiopathic Pulmonary Fibrosis.<b>Rationale:</b> Several common and rare genetic variants have been associated with idiopathic pulmonary fibrosis, a progressive fibrotic condition that is localized to the lung. <b>Objectives:</b> To develop an integrated understanding of the rare and common variants located in multiple loci that have been reported to contribute to the risk of disease. <b>Methods:</b> We performed deep targeted resequencing (3.69 Mb of DNA) in cases (<i>n</i> = 3,624) and control subjects (<i>n</i> = 4,442) across genes and regions previously associated with disease. We tested for associations between disease and <i>1</i>) individual common variants via logistic regression and <i>2</i>) groups of rare variants via sequence kernel association tests. <b>Measurements and Main Results:</b> Statistically sign2019-01-01T00:00:00Z2019 Jul2025-06-01T02:35:51.208Z2025-06-01T02:35:51.208ZS-EPMC66357913103427910.1164/rccm.201810-1891OC10.1164/rccm.201810-1891oc