biostudies-literatureSeroogy CMNCATS NIH HHSNIAID NIH HHSNational Institutes of HealthNIH HHSMarshfield Clinic Health System Foundation423https://www.ebi.ac.uk/biostudies/studies/S-EPMC6636141biostudies-literatureUnknown12(1)Epidemiologic and cross-sectional studies suggest that early life farming and animal exposures are associated with major health benefits, influencing immune development and modifying the subsequent risk of allergic diseases, including asthma. The Wisconsin Infant Study Cohort (WISC) study was established in central Wisconsin to test the hypothesis that early life animal farm exposures are associated with distinct innate immune cell maturation trajectories, decreased allergen sensitization and reduced respiratory viral illness burden during the first 2 years of life. Beginning in 2013, a total of 240 families have been enrolled, 16,522 biospecimens have been collected, and 4098 questionnaires have been administered and entered into a secure database. Study endpoints include nasal respiratorBMC research notesRespiratory health, allergies, and the farm environment: design, methods and enrollment in the observational Wisconsin Infant Study Cohort (WISC): a research proposal.PMC6636141UL1 TR002373U19 AI104317UL1TR000427U54 OH010170Entire WISC Study TeamKoepel TKOlson BFBendixsen CGvon Mutius ECole DGangnon REJohnson TGern JESeroogy CMBarnes KLMeece JVanWormer JJKeifer MCDresen AEvans MDSigelman STogias AfalseRespiratory health, allergies, and the farm environment: design, methods and enrollment in the observational Wisconsin Infant Study Cohort (WISC): a research proposal.Epidemiologic and cross-sectional studies suggest that early life farming and animal exposures are associated with major health benefits, influencing immune development and modifying the subsequent risk of allergic diseases, including asthma. The Wisconsin Infant Study Cohort (WISC) study was established in central Wisconsin to test the hypothesis that early life animal farm exposures are associated with distinct innate immune cell maturation trajectories, decreased allergen sensitization and reduced respiratory viral illness burden during the first 2 years of life. Beginning in 2013, a total of 240 families have been enrolled, 16,522 biospecimens have been collected, and 4098 questionnaires have been administered and entered into a secure database. Study endpoints include nasal respirator2019-01-01T00:00:00Z2019 Jul2025-04-05T10:41:54.885Z2019-07-30T07:07:03ZS-EPMC66361413131158810.1186/s13104-019-4448-0