{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li X"],"funding":["National Institutes of Health, USA","Natural Science Foundation of Guangdong","NSFC","NIAID NIH HHS","National Natural Science Foundation of China"],"pagination":["92-105"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6636634"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["109"],"pubmed_abstract":["In Drosophila melanogaster, transformer-2 (tra2) plays an essential role in the sex-specific splicing of doublesex (dsx) and fruitless (fru), two key transcription factor genes that program sexual differentiation and regulate sexual behavior. In the present study, the sequences and expression profiles of three tra2 (Aalbtra2) genes in the Asian tiger mosquito, Aedes albopictus (Ae. albopictus) were characterized. Phylogenetic analysis revealed that these paralogs resulted from two duplication events. The first occurred in the common ancestor of Culicidae, giving rise to the tra2-α and tra2-β clades that are found across divergent mosquito genera, including Aedes, Culex, and Anopheles. The second occurred within the tra2-α clade, giving rise to tra2-γ in Ae. albopictus. In addition to the c"],"journal":["Insect biochemistry and molecular biology"],"pubmed_title":["Two of the three Transformer-2 genes are required for ovarian development in Aedes albopictus."],"pmcid":["PMC6636634"],"funding_grant_id":["81672054","2014A030312016","R01 AI123338","AI123338","81420108024"],"pubmed_authors":["Li X","Dong Y","Jin B","Gu J","Chen X","Tu Z"],"additional_accession":[]},"is_claimable":false,"name":"Two of the three Transformer-2 genes are required for ovarian development in Aedes albopictus.","description":"In Drosophila melanogaster, transformer-2 (tra2) plays an essential role in the sex-specific splicing of doublesex (dsx) and fruitless (fru), two key transcription factor genes that program sexual differentiation and regulate sexual behavior. In the present study, the sequences and expression profiles of three tra2 (Aalbtra2) genes in the Asian tiger mosquito, Aedes albopictus (Ae. albopictus) were characterized. Phylogenetic analysis revealed that these paralogs resulted from two duplication events. The first occurred in the common ancestor of Culicidae, giving rise to the tra2-α and tra2-β clades that are found across divergent mosquito genera, including Aedes, Culex, and Anopheles. The second occurred within the tra2-α clade, giving rise to tra2-γ in Ae. albopictus. In addition to the c","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Jun","modification":"2026-04-08T02:33:50.48Z","creation":"2020-10-29T11:47:37Z"},"accession":"S-EPMC6636634","cross_references":{"pubmed":["30914323"],"doi":["10.1016/j.ibmb.2019.03.008"]}}