biostudies-literaturePathak CScience and Engineering Research BoardUniversity Grants CommissionCouncil of Scientific and Industrial Research4737-4750https://www.ebi.ac.uk/biostudies/studies/S-EPMC6641979biostudies-literatureUnknown2(8)The active site of the purple acid phosphatase enzyme has been successfully modeled by a series of hetero-dinuclear M(II)-Fe(III) [M = Zn, Ni, Co, and Cu] type complexes of an unsymmetrical [N₆O] ligand that contained a bridging phenoxide moiety and one imidazoyl and three pyridyl moieties as the terminal N-binding sites. In particular, the hetero-dinuclear complexes, {L[M^II(μ-OAc)₂Fe^III]}(ClO₄)₂ [M = Zn (<b>3a</b>), Ni (<b>3b</b>), Co (<b>4a</b>), and Cu (<b>4b</b>)], were obtained directly from the phenoxy-bridged ligand (HL), namely 2-{[bis(2-methylpyridyl)amino]methyl}-6-{[((1-methylimidazol-2-yl)methyl)(2-pyridylmethyl)amino]methyl}-4-<i>t</i>-butylphenol (<b>2</b>), upon sequential addition of Fe(ClO₄)<sub>3ACS omegaModeling the Active Site of the Purple Acid Phosphatase Enzyme with Hetero-Dinuclear Mixed Valence M(II)-Fe(III) [M = Zn, Ni, Co, and Cu] Complexes Supported over a [N₆O] Unsymmetrical Ligand.PMC6641979EMR/2014/000254Prakasham APPathak CGangwar MKGupta SKGhosh PfalseModeling the Active Site of the Purple Acid Phosphatase Enzyme with Hetero-Dinuclear Mixed Valence M(II)-Fe(III) [M = Zn, Ni, Co, and Cu] Complexes Supported over a [N₆O] Unsymmetrical Ligand.The active site of the purple acid phosphatase enzyme has been successfully modeled by a series of hetero-dinuclear M(II)-Fe(III) [M = Zn, Ni, Co, and Cu] type complexes of an unsymmetrical [N₆O] ligand that contained a bridging phenoxide moiety and one imidazoyl and three pyridyl moieties as the terminal N-binding sites. In particular, the hetero-dinuclear complexes, {L[M^II(μ-OAc)₂Fe^III]}(ClO₄)₂ [M = Zn (<b>3a</b>), Ni (<b>3b</b>), Co (<b>4a</b>), and Cu (<b>4b</b>)], were obtained directly from the phenoxy-bridged ligand (HL), namely 2-{[bis(2-methylpyridyl)amino]methyl}-6-{[((1-methylimidazol-2-yl)methyl)(2-pyridylmethyl)amino]methyl}-4-<i>t</i>-butylphenol (<b>2</b>), upon sequential addition of Fe(ClO₄)<sub>32017-01-01T00:00:00Z2017 Aug2025-05-18T13:15:40.564Z2025-05-18T13:15:40.564ZS-EPMC66419793145775710.1021/acsomega.7b00671