{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zuo Y"],"funding":["Natural Science Foundation of Anhui Province","National Natural Science Foundation of China"],"pagination":["8507-8516"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6645244"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2(11)"],"pubmed_abstract":["A Rh(III)-catalyzed C-H activation/cyclization cascade reaction is described. The reaction involves cyclic 2-diazo-1,3-diketones and <i>N</i>-arylamides, and it proceeds via an intermolecular C-C bond formation and subsequent intramolecular C-N bond formation. A variety of <i>N</i>-acyl-2,3-dihydro-1<i>H</i>-carbazol-4(9<i>H</i>)-ones were obtained under mild conditions in good to excellent yields (65-90%). Key features of this strategy include high-efficiency, operational simplicity, scalability, and broad functional-group tolerance. In addition, H<sub>2</sub>O and N<sub>2</sub> are the only byproducts. Carbazole derivatives with free NH groups can be easily obtained through <i>N</i>-deprotection reactions."],"journal":["ACS omega"],"pubmed_title":["Rh(III)-Catalyzed C-H Activation/Intramolecular Cyclization: Access to <i>N</i>-Acyl-2,3-dihydro-1<i>H</i>-carbazol-4(9<i>H</i>)-ones from Cyclic 2-Diazo-1,3-diketones and <i>N</i>-Arylamides."],"pmcid":["PMC6645244"],"funding_grant_id":["KJ2016A267","21372008","21772001"],"pubmed_authors":["Zuo Y","He X","Ning Y","Shang Y","Wu Y"],"additional_accession":[]},"is_claimable":false,"name":"Rh(III)-Catalyzed C-H Activation/Intramolecular Cyclization: Access to <i>N</i>-Acyl-2,3-dihydro-1<i>H</i>-carbazol-4(9<i>H</i>)-ones from Cyclic 2-Diazo-1,3-diketones and <i>N</i>-Arylamides.","description":"A Rh(III)-catalyzed C-H activation/cyclization cascade reaction is described. The reaction involves cyclic 2-diazo-1,3-diketones and <i>N</i>-arylamides, and it proceeds via an intermolecular C-C bond formation and subsequent intramolecular C-N bond formation. A variety of <i>N</i>-acyl-2,3-dihydro-1<i>H</i>-carbazol-4(9<i>H</i>)-ones were obtained under mild conditions in good to excellent yields (65-90%). Key features of this strategy include high-efficiency, operational simplicity, scalability, and broad functional-group tolerance. In addition, H<sub>2</sub>O and N<sub>2</sub> are the only byproducts. Carbazole derivatives with free NH groups can be easily obtained through <i>N</i>-deprotection reactions.","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Nov","modification":"2025-04-05T10:42:16.176Z","creation":"2019-08-31T07:04:24Z"},"accession":"S-EPMC6645244","cross_references":{"pubmed":["31457387"],"doi":["10.1021/acsomega.7b01637"]}}