{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["DEFINE-FLAIR Trial Investigators"],"funding":["Medical Research Council","National Institute for Health Research (NIHR)"],"pagination":["857-864"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6646975"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["4(9)"],"pubmed_abstract":["<h4>Importance</h4>Invasive physiologic indices such as fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR) are used in clinical practice. Nevertheless, comparative prognostic outcomes of iFR-guided and FFR-guided treatment in patients with type 2 diabetes have not yet been fully investigated.<h4>Objective</h4>To compare 1-year clinical outcomes of iFR-guided or FFR-guided treatment in patients with and without diabetes in the Functional Lesion Assessment of Intermediate Stenosis to Guide Revascularization (DEFINE-FLAIR) trial.<h4>Design, setting, and participants</h4>The DEFINE-FLAIR trial is a multicenter, international, randomized, double-blinded trial that randomly assigned 2492 patients in a 1:1 ratio to undergo either iFR-guided or FFR-guided coronary revascularizat"],"journal":["JAMA cardiology"],"pubmed_title":["Comparison of Major Adverse Cardiac Events Between Instantaneous Wave-Free Ratio and Fractional Flow Reserve-Guided Strategy in Patients With or Without Type 2 Diabetes: A Secondary Analysis of a Randomized Clinical Trial."],"pmcid":["PMC6646975"],"funding_grant_id":["G1100443","ACF-2010-21-008","CL-2015-21-001"],"pubmed_authors":["Matsuo H","Sezer M","Baptista SB","Vinhas H","Janssens L","Samuels B","Malik IS","DEFINE-FLAIR Trial Investigators","Singh J","Petraco R","Nijjer SS","Sapontis J","Lee JM","Mejia-Renteria H","van Royen N","Erglis A","Sharp ASP","Krackhardt F","Shin ES","Alghamdi A","Van Belle E","Sen S","Seto AH","Escaned J","Walters D","Lehman SJ","Going O","Hellig F","Vrints CJ","Samady H","Indolfi C","Laine M","Khashaba A","Niccoli G","Dehbi HM","Bojara W","Takashima H","Ribichini F","Tang K","Davies JE","Koo BK","Patel MR","Harle T","Talwar S","Tanaka N","Cook CM","Brugaletta S","Piek JJ","Al-Lamee R","Meuwissen M","Kharbanda RK","Kikuta Y","Alegria-Barrero E","Buller C","Gerber RT","Serruys P","Doh JH","Silva PC","Altman J","Jeremias A","Nam CW","Di Mario C","Choi KH","Yokoi H","Bhindi R"],"additional_accession":[]},"is_claimable":false,"name":"Comparison of Major Adverse Cardiac Events Between Instantaneous Wave-Free Ratio and Fractional Flow Reserve-Guided Strategy in Patients With or Without Type 2 Diabetes: A Secondary Analysis of a Randomized Clinical Trial.","description":"<h4>Importance</h4>Invasive physiologic indices such as fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR) are used in clinical practice. Nevertheless, comparative prognostic outcomes of iFR-guided and FFR-guided treatment in patients with type 2 diabetes have not yet been fully investigated.<h4>Objective</h4>To compare 1-year clinical outcomes of iFR-guided or FFR-guided treatment in patients with and without diabetes in the Functional Lesion Assessment of Intermediate Stenosis to Guide Revascularization (DEFINE-FLAIR) trial.<h4>Design, setting, and participants</h4>The DEFINE-FLAIR trial is a multicenter, international, randomized, double-blinded trial that randomly assigned 2492 patients in a 1:1 ratio to undergo either iFR-guided or FFR-guided coronary revascularizat","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Sep","modification":"2026-04-30T03:56:12.215Z","creation":"2025-06-01T02:35:45.033Z"},"accession":"S-EPMC6646975","cross_references":{"pubmed":["31314045"],"doi":["10.1001/jamacardio.2019.2298"]}}