biostudies-literatureDEFINE-FLAIR Trial InvestigatorsMedical Research CouncilNational Institute for Health Research (NIHR)857-864https://www.ebi.ac.uk/biostudies/studies/S-EPMC6646975biostudies-literatureUnknown4(9)<h4>Importance</h4>Invasive physiologic indices such as fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR) are used in clinical practice. Nevertheless, comparative prognostic outcomes of iFR-guided and FFR-guided treatment in patients with type 2 diabetes have not yet been fully investigated.<h4>Objective</h4>To compare 1-year clinical outcomes of iFR-guided or FFR-guided treatment in patients with and without diabetes in the Functional Lesion Assessment of Intermediate Stenosis to Guide Revascularization (DEFINE-FLAIR) trial.<h4>Design, setting, and participants</h4>The DEFINE-FLAIR trial is a multicenter, international, randomized, double-blinded trial that randomly assigned 2492 patients in a 1:1 ratio to undergo either iFR-guided or FFR-guided coronary revascularizatJAMA cardiologyComparison of Major Adverse Cardiac Events Between Instantaneous Wave-Free Ratio and Fractional Flow Reserve-Guided Strategy in Patients With or Without Type 2 Diabetes: A Secondary Analysis of a Randomized Clinical Trial.PMC6646975G1100443ACF-2010-21-008CL-2015-21-001Matsuo HSezer MBaptista SBVinhas HJanssens LSamuels BMalik ISDEFINE-FLAIR Trial InvestigatorsSingh JPetraco RNijjer SSSapontis JLee JMMejia-Renteria Hvan Royen NErglis ASharp ASPKrackhardt FShin ESAlghamdi AVan Belle ESen SSeto AHEscaned JWalters DLehman SJGoing OHellig FVrints CJSamady HIndolfi CLaine MKhashaba ANiccoli GDehbi HMBojara WTakashima HRibichini FTang KDavies JEKoo BKPatel MRHarle TTalwar STanaka NCook CMBrugaletta SPiek JJAl-Lamee RMeuwissen MKharbanda RKKikuta YAlegria-Barrero EBuller CGerber RTSerruys PDoh JHSilva PCAltman JJeremias ANam CWDi Mario CChoi KHYokoi HBhindi RfalseComparison of Major Adverse Cardiac Events Between Instantaneous Wave-Free Ratio and Fractional Flow Reserve-Guided Strategy in Patients With or Without Type 2 Diabetes: A Secondary Analysis of a Randomized Clinical Trial.<h4>Importance</h4>Invasive physiologic indices such as fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR) are used in clinical practice. Nevertheless, comparative prognostic outcomes of iFR-guided and FFR-guided treatment in patients with type 2 diabetes have not yet been fully investigated.<h4>Objective</h4>To compare 1-year clinical outcomes of iFR-guided or FFR-guided treatment in patients with and without diabetes in the Functional Lesion Assessment of Intermediate Stenosis to Guide Revascularization (DEFINE-FLAIR) trial.<h4>Design, setting, and participants</h4>The DEFINE-FLAIR trial is a multicenter, international, randomized, double-blinded trial that randomly assigned 2492 patients in a 1:1 ratio to undergo either iFR-guided or FFR-guided coronary revascularizat2019-01-01T00:00:00Z2019 Sep2026-04-30T03:56:12.215Z2025-06-01T02:35:45.033ZS-EPMC66469753131404510.1001/jamacardio.2019.2298